| Reaction Details |
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 | Report a problem with these data |
| Target | Delta-type opioid receptor |
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| Ligand | BDBM50108789 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_145488 (CHEMBL752131) |
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| Ki | 24±n/a nM |
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| Citation |  Srivastava, SK; Husbands, SM; Aceto, MD; Miller, CN; Traynor, JR; Lewis, JW 4'-Arylpyrrolomorphinans: effect of a pyrrolo-N-benzyl substituent in enhancing delta-opioid antagonist activity. J Med Chem45:537-40 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Delta-type opioid receptor |
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| Name: | Delta-type opioid receptor |
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| Synonyms: | D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 40382.98 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor. |
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| Residue: | 372 |
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| Sequence: | MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVC
AVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELL
CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVG
VPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRL
RSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAAL
HLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTAC
TPSDGPGGGAAA
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| BDBM50108789 |
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| n/a |
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| Name | BDBM50108789 |
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| Synonyms: | 7-benzyl-18-cyclopropylmethyl-5-(4-methylphenyl)-10-oxa-7,18-diazahexacyclo[9.9.1.01,9.02,17.04,8.015,21]henicosa-4(8),5,11,13,15(21)-pentaene-2,12-diol | CHEMBL356473 |
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| Type | Small organic molecule |
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| Emp. Form. | C36H36N2O3 |
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| Mol. Mass. | 544.6826 |
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| SMILES | Cc1ccc(cc1)-c1cn(Cc2ccccc2)c2[C@@H]3Oc4c5c(CC6N(CC7CC7)CC[C@@]35[C@@]6(O)Cc12)ccc4O |TLB:37:22:33:25.31.30,20:21:33:25.31.30| |
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| Structure | 
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