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TargetMelanocortin receptor 5
LigandBDBM50121266
Substrate/Competitorn/a
Meas. Tech.ChEMBL_106526 (CHEMBL713030)
IC50 0.11±n/a nM
Citation Grieco, PLavecchia, ACai, MTrivedi, DWeinberg, DMacNeil, TVan der Ploeg, LHHruby, VJ Structure-activity studies of the melanocortin peptides: discovery of potent and selective affinity antagonists for the hMC3 and hMC4 receptors. J Med Chem45:5287-94 (2002) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Melanocortin receptor 5
Name:Melanocortin receptor 5
Synonyms:MC-2 | MC5-R | MC5R | MC5R_HUMAN | Melanocortin MC5 | Melanocortin receptor (M4 and M5) | Melanocortin receptor 5 | Melanocortin receptor 5 (MC5R)
Type:Enzyme
Mol. Mass.:36612.92
Organism:Homo sapiens (Human)
Description:P33032
Residue:325
Sequence:
MNSSFHLHFLDLNLNATEGNLSGPNVKNKSSPCEDMGIAVEVFLTLGVISLLENILVIGA
IVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETITIYLLNNKHLVIADAFVRHIDNVFDS
MICISVVASMCSLLAIAVDRYVTIFYALRYHHIMTARRSGAIIAGIWAFCTGCGIVFILY
SESTYVILCLISMFFAMLFLLVSLYIHMFLLARTHVKRIAALPGASSARQRTSMQGAVTV
TMLLGVFTVCWAPFFLHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAFRSQ
EMRKTFKEIICCRGFRIACSFPRRD
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  Blast E-value cutoff:
BDBM50121266
n/a
NameBDBM50121266
Synonyms:21-(2-Acetylamino-hexanoylamino)-7-[3-(diaminomethaniminium)-propyl]-10-(1H-indol-3-ylmethyl)-24,29-dimethyl-4-naphthalen-2-ylmethyl-2,5,8,11,19,22-hexaoxo-3,6,9,12,18,23-hexaaza-tricyclo[21.7.0.0*24,29*]triacontane-13-carboxylic acid amide | CID44366380 | PG-913
TypeSmall organic molecule
Emp. Form.C59H82N13O9
Mol. Mass.1117.3635
SMILESCCCC[C@@H](NC(C)=O)C(=O)N[C@@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCNC(N)=[NH2+])NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H]2C[C@@]3(C)CCCC[C@@]3(C)N2C1=O)C(N)=O
Structure
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