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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | ATP-dependent translocase ABCB1 | ||
| Ligand | BDBM50121978 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_147865 (CHEMBL755181) | ||
| IC50 | 500±n/a nM | ||
| Citation |  Pajeva, IK; Wiese, M Pharmacophore model of drugs involved in P-glycoprotein multidrug resistance: explanation of structural variety (hypothesis). J Med Chem45:5671-86 (2002) [PubMed] | ||
| More Info.: | Get all data from this article, Assay Method | ||
| ATP-dependent translocase ABCB1 | |||
| Name: | ATP-dependent translocase ABCB1 | ||
| Synonyms: | ABCB1 | MDR1 | MDR1_HUMAN | Multidrug Resistance Transporter MDR 1 | Multidrug resistance protein 1 | Multidrug resistance protein 1/Multidrug resistance associated protein 1 | P-glycoprotein (P-gp) | P-glycoprotein 1 | PGY1 | ||
| Type: | Protein | ||
| Mol. Mass.: | 141503.50 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P08183 | ||
| Residue: | 1280 | ||
| Sequence: |
| ||
| BDBM50121978 | |||
| n/a | |||
| Name | BDBM50121978 | ||
| Synonyms: | 2-(6-Amino-3-imino-3H-xanthen-9-yl)-benzoic acid methyl ester | CHEMBL347534 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H16N2O3 | ||
| Mol. Mass. | 344.3633 | ||
| SMILES | COC(=O)c1ccccc1-c1c2ccc(N)cc2oc2cc(=N)ccc12 |(6.77,-8.35,;6.76,-6.81,;5.42,-6.05,;6.51,-4.95,;4.09,-6.83,;4.09,-8.37,;2.76,-9.15,;1.43,-8.37,;1.43,-6.83,;2.76,-6.07,;2.76,-4.53,;4.11,-3.75,;5.41,-4.51,;6.79,-3.75,;6.77,-2.2,;8.1,-1.43,;5.44,-1.43,;4.11,-2.2,;2.76,-1.42,;1.43,-2.2,;.09,-1.43,;-1.24,-2.22,;-2.57,-1.45,;-1.24,-3.75,;.09,-4.52,;1.42,-3.76,)| | ||
| Structure | 
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