Reaction Details |
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Target | Interstitial collagenase |
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Ligand | BDBM50109622 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_106139 (CHEMBL718686) |
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Ki | 6.67±n/a nM |
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Citation | Sawa, M; Kiyoi, T; Kurokawa, K; Kumihara, H; Yamamoto, M; Miyasaka, T; Ito, Y; Hirayama, R; Inoue, T; Kirii, Y; Nishiwaki, E; Ohmoto, H; Maeda, Y; Ishibushi, E; Inoue, Y; Yoshino, K; Kondo, H New type of metalloproteinase inhibitor: design and synthesis of new phosphonamide-based hydroxamic acids. J Med Chem45:919-29 (2002) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Interstitial collagenase |
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Name: | Interstitial collagenase |
Synonyms: | CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1) |
Type: | Enzyme |
Mol. Mass.: | 54010.26 |
Organism: | Homo sapiens (Human) |
Description: | P03956 |
Residue: | 469 |
Sequence: | MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPV
VEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIEN
YTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGN
LAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSY
TFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDR
FYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGY
PKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFP
GIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
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BDBM50109622 |
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n/a |
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Name | BDBM50109622 |
Synonyms: | (3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-yl)-(4-methoxy-phenyl)-phosphinic acid cyclohexylmethyl ester | CHEMBL173846 |
Type | Small organic molecule |
Emp. Form. | C24H31N2O5P |
Mol. Mass. | 458.4871 |
SMILES | COc1ccc(cc1)P(=O)(OCC1CCCCC1)N1Cc2ccccc2CC1C(=O)NO |
Structure |
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