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TargetInterstitial collagenase
LigandBDBM50109629
Substrate/Competitorn/a
Meas. Tech.ChEMBL_106139 (CHEMBL718686)
Ki 0.97±n/a nM
Citation Sawa, MKiyoi, TKurokawa, KKumihara, HYamamoto, MMiyasaka, TIto, YHirayama, RInoue, TKirii, YNishiwaki, EOhmoto, HMaeda, YIshibushi, EInoue, YYoshino, KKondo, H New type of metalloproteinase inhibitor: design and synthesis of new phosphonamide-based hydroxamic acids. J Med Chem45:919-29 (2002) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Interstitial collagenase
Name:Interstitial collagenase
Synonyms:CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1)
Type:Enzyme
Mol. Mass.:54010.26
Organism:Homo sapiens (Human)
Description: P03956
Residue:469
Sequence:
MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPV
VEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIEN
YTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGN
LAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSY
TFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDR
FYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGY
PKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFP
GIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50109629
n/a
NameBDBM50109629
Synonyms:(4-Fluoro-phenyl)-(3-hydroxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-yl)-phosphinic acid ethyl ester | CHEMBL172885
TypeSmall organic molecule
Emp. Form.C18H20FN2O4P
Mol. Mass.378.3346
SMILESCCOP(=O)(N1Cc2ccccc2CC1C(=O)NO)c1ccc(F)cc1
Structure
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