| Reaction Details |
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 | Report a problem with these data |
| Target | Interstitial collagenase |
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| Ligand | BDBM50109635 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_106139 (CHEMBL718686) |
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| Ki | 1.81±n/a nM |
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| Citation |  Sawa, M; Kiyoi, T; Kurokawa, K; Kumihara, H; Yamamoto, M; Miyasaka, T; Ito, Y; Hirayama, R; Inoue, T; Kirii, Y; Nishiwaki, E; Ohmoto, H; Maeda, Y; Ishibushi, E; Inoue, Y; Yoshino, K; Kondo, H New type of metalloproteinase inhibitor: design and synthesis of new phosphonamide-based hydroxamic acids. J Med Chem45:919-29 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Interstitial collagenase |
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| Name: | Interstitial collagenase |
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| Synonyms: | CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 54010.26 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P03956 |
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| Residue: | 469 |
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| Sequence: | MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPV
VEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIEN
YTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGN
LAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSY
TFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDR
FYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGY
PKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFP
GIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
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| BDBM50109635 |
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| n/a |
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| Name | BDBM50109635 |
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| Synonyms: | (3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-yl)-(4-phenoxy-phenyl)-phosphinic acid ethyl ester | CHEMBL355797 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H25N2O5P |
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| Mol. Mass. | 452.4395 |
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| SMILES | CCOP(=O)(N1Cc2ccccc2CC1C(=O)NO)c1ccc(Oc2ccccc2)cc1 |
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| Structure | 
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