Ki Summary

Reaction Details

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Target

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B

Ligand

BDBM50110693

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_198013 (CHEMBL799065)

IC50

3.4±n/a nM

Citation

McCluskey, A; Sim, AT; Sakoff, JA Serine-threonine protein phosphatase inhibitors: development of potential therapeutic strategies. J Med Chem45:1151-75 (2002) [PubMed]

More Info.:

Get all data from this article, Assay Method

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B

Name:

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B

Synonyms:

Serine-threonine protein phosphatase 2A regulatory subunit

Type:

PROTEIN

Mol. Mass.:

49694.81

Organism:

Gallus gallus

Description:

ChEMBL_161937

Residue:

426

Sequence:

DDDVAEADIISTVEFNHCGELLATGDKGGRVVIFQQEQENKIQSHSRGEYNVYSTFQSHE
PEFDYLKSLEIEEKINKIRWLPQKNAAQFLLSTNDKTIKLWKISERDKRPEGYNLKEEDG
RYRDPTTVTTLRVPVFRPMDLMVEASPRRIFANAHTYHINSISINSDYETYLSADDLRIN
LWHLEITDRSFNIVDIKPANMEELTEVITAAEFHPNSCNTFVYSSSKGTIRLCDMRASAL
CDRHSKLFEEPEDPSNRSFFSEIISSISDVKFSHSGRYMMTRDYLSVKIWDLNMENRPVE
TYQVHEYLRSKLCSLYENDCIFDKFECCWNGSDSVVMTGSYNNFFRMFDRNTKRDITLEA
SRENNKPRTVLKPRKVCASGKRKKDEISVDSLDFNKKILHHAWHPKENIIAVATTNNLYI
FQDKMN

BDBM50110693

n/a

Name

BDBM50110693

Synonyms:

25-Cyclohexylmethyl-15-(6-methoxy-3,5-dimethyl-7-phenyl-hepta-1,3-dienyl)-3,7,14,18,21-pentamethyl-6-methylene-2,5,8,13,17,20,24-heptaoxo-1,4,7,12,16,19hexaaza-cyclopentacosane-11,22-dicarboxylic acid | CHEMBL17060

Type

Small organic molecule

Emp. Form.

C50H72N6O12

Mol. Mass.

949.1397

SMILES

CO[C@@H](Cc1ccccc1)[C@@H](C)\C=C(/C)\C=C\[C@@H]1NC(=O)[C@H](C)NC(=O)[C@@H](C)[C@@H](CC(=O)[C@H](CC2CCCCC2)NC(=O)[C@@H](C)NC(=O)C(=C)N(C)C(=O)CC[C@@H](NC(=O)[C@H]1C)C(O)=O)C(O)=O

Structure