Reaction Details | |||
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Target | Kappa-type opioid receptor | ||
Ligand | BDBM50122550 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_145111 (CHEMBL751994) | ||
IC50 | 1200±n/a nM | ||
Citation | Hanessian, S; Parthasarathy, S; Mauduit, M; Payza, K The power of visual imagery in drug design. Isopavines as a new class of morphinomimetics and their human opioid receptor binding activity. J Med Chem46:34-48 (2002) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Kappa-type opioid receptor | |||
Name: | Kappa-type opioid receptor | ||
Synonyms: | K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR) | ||
Type: | G Protein-Coupled Receptor (GPCR) | ||
Mol. Mass.: | 42648.76 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P41145 | ||
Residue: | 380 | ||
Sequence: |
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BDBM50122550 | |||
n/a | |||
Name | BDBM50122550 | ||
Synonyms: | 4N,13N-diphenyl-17-cyclopropylmethyl-16-methyl-(9S,16R)-17-azatetracyclo[7.6.2.02,7.010,15]heptadeca-2(7),3,5,12,14-pentaene-4,13-diamine | ||
Type | Small organic molecule | ||
Emp. Form. | C33H35N3 | ||
Mol. Mass. | 473.6511 | ||
SMILES | C[C@@H]1[C@@H]2C3=CC(CC[C@H]3[C@H](Cc3ccc(Nc4ccccc4)cc23)N1CC1CC1)=Nc1ccccc1 |w:29.35,wU:2.2,9.27,8.7,1.0,t:3,TLB:0:1:3.8:23.11.10,22:23:24.1:3.8,THB:12:11:24.1:3.8,25:24:3.8:23.11.10,7:8:24.1:23.11.10,(11.78,-2.83,;10.69,-3.93,;6.86,-2.67,;6.86,-1.13,;6.86,.42,;8.19,1.19,;9.53,.42,;9.53,-1.13,;8.19,-1.9,;8.41,-5.76,;6.86,-5.76,;5.53,-4.99,;4.2,-5.76,;2.85,-4.99,;2.85,-3.45,;1.52,-2.66,;.17,-3.41,;-1.16,-2.64,;-2.49,-3.39,;-2.5,-4.93,;-1.17,-5.72,;.17,-4.95,;4.2,-2.67,;5.53,-3.44,;9.85,-5.21,;10.8,-6.4,;10.24,-7.85,;9.05,-8.8,;10.48,-9.36,;8.19,2.73,;6.84,3.5,;6.86,5.06,;5.53,5.83,;4.18,5.06,;4.2,3.5,;5.53,2.75,)| | ||
Structure |