| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 2D26 |
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| Ligand | BDBM112777 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_51710 (CHEMBL665725) |
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| IC50 | 1900±n/a nM |
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| Citation |  Venhorst, J; ter Laak, AM; Commandeur, JN; Funae, Y; Hiroi, T; Vermeulen, NP Homology modeling of rat and human cytochrome P450 2D (CYP2D) isoforms and computational rationalization of experimental ligand-binding specificities. J Med Chem46:74-86 (2002) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome P450 2D26 |
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| Name: | Cytochrome P450 2D26 |
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| Synonyms: | CP2DQ_RAT | CYPIID26 | Cyp2d-26 | Cyp2d2 | Cyp2d26 | Cytochrome P450 2D2 | Cytochrome P450 2D26 | Debrisoquine 4-hydroxylase | P450-CMF2 | P450-DB2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 56689.75 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_51710 |
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| Residue: | 500 |
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| Sequence: | MGLLIGDDLWAVVIFTAIFLLLVDLVHRHKFWTAHYPPGPVPLPGLGNLLQVDFENMPYS
LYKLRSRYGDVFSLQIAWKPVVVINGLKAVRELLVTYGEDTADRPLLPIYNHLGYGNKSK
GVVLAPYGPEWREQRRFSVSTLRDFGVGKKSLEQWVTEEAGHLCDTFAKEAEHPFNPSIL
LSKAVSNVIASLVYARRFEYEDPFFNRMLKTLKESFGEDTGFMAEVLNAIPILLQIPGLP
GKVFPKLNSFIALVDKMLIEHKKSWDPAQPPRDMTDAFLAEMQKAKGNPESSFNDENLRL
VVIDLFMAGMVTTSTTLSWALLLMILHPDVQRRVHEEIDEVIGQVRRPEMADQARMPFTN
AVIHEVQRFADIVPTNIPHMTSRDIKFQGFLIPKGTTLIPNLSSVLKDETVWEKPLRFHP
EHFLDAQGNFVKHEAFMPFSAGRRACLGEPLARMELFLFFTCLLQRFSFSVLAGRPRPST
HGVYALPVTPQPYQLCAVAR
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| BDBM112777 |
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| n/a |
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| Name | BDBM112777 |
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| Synonyms: | NORTRIPTYLINE | US8629135, SW-02 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H21N |
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| Mol. Mass. | 263.3767 |
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| SMILES | [#6]-[#7]-[#6]-[#6]\[#6]=[#6]-1/c2ccccc2-[#6]-[#6]-c2ccccc-12 |
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| Structure | 
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