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TargetCytochrome P450 2D1
LigandBDBM36108
Substrate/Competitorn/a
Meas. Tech.ChEMBL_51708
IC50 182000±n/a nM
Citation Venhorst Jter Laak AMCommandeur JNFunae YHiroi TVermeulen NP Homology modeling of rat and human cytochrome P450 2D (CYP2D) isoforms and computational rationalization of experimental ligand-binding specificities. J Med Chem 46:74-86 (2002) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cytochrome P450 2D1
Name:Cytochrome P450 2D1
Synonyms:CYPIID1 | Debrisoquine 4-hydroxylase | P450-CMF1A | P450-DB1 | P450-UT-7
Type:PROTEIN
Mol. Mass.:57179.81
Organism:Rattus norvegicus
Description:ChEMBL_51708
Residue:504
Sequence:
MELLNGTGLWSMAIFTVIFILLVDLMHRRHRWTSRYPPGPVPWPVLGNLLQVDLSNMPYS
LYKLQHRYGDVFSLQKGWKPMVIVNRLKAVQEVLVTHGEDTADRPPVPIFKCLGVKPRSQ
GVILASYGPEWREQRRFSVSTLRTFGMGKKSLEEWVTKEAGHLCDAFTAQAGQSINPKAM
LNKALCNVIASLIFARRFEYEDPYLIRMVKLVEESLTEVSGFIPEVLNTFPALLRIPGLA
DKVFQGQKTFMALLDNLLAENRTTWDPAQPPRNLTDAFLAEVEKAKGNPESSFNDENLRM
VVVDLFTAGMVTTATTLTWALLLMILYPDVQRRVQQEIDEVIGQVRCPEMTDQAHMPYTN
AVIHEVQRFGDIAPLNLPRFTSCDIEVQDFVIPKGTTLIINLSSVLKDETVWEKPHRFHP
EHFLDAQGNFVKHEAFMPFSAGRRACLGEPLARMELFLFFTCLLQRFSFSVPVGQPRPST
HGFFAFPVAPLPYQLCAVVREQGL
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  Blast E-value cutoff:
BDBM36108
n/a
NameBDBM36108
Synonyms:(R)-propranolol
TypeGuest
Emp. Form.C16H22NO2
Mol. Mass.260.3508
SMILESCC(C)[NH2+]C[C@@H](O)COc1cccc2ccccc12
Structure
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