| Reaction Details |
|---|
 | Report a problem with these data |
| Target | B1 bradykinin receptor |
|---|
| Ligand | BDBM50370216 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_40137 (CHEMBL656789) |
|---|
| IC50 | 24.2±n/a nM |
|---|
| Citation |  Wood, MR; Kim, JJ; Han, W; Dorsey, BD; Homnick, CF; DiPardo, RM; Kuduk, SD; MacNeil, T; Murphy, KL; Lis, EV; Ransom, RW; Stump, GL; Lynch, JJ; O'Malley, SS; Miller, PJ; Chen, TB; Harrell, CM; Chang, RS; Sandhu, P; Ellis, JD; Bondiskey, PJ; Pettibone, DJ; Freidinger, RM; Bock, MG Benzodiazepines as potent and selective bradykinin B1 antagonists. J Med Chem46:1803-6 (2003) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| B1 bradykinin receptor |
|---|
| Name: | B1 bradykinin receptor |
|---|
| Synonyms: | B1 BRADYKININ | B1R | B1bkr | BK-1 receptor | BKRB1_RAT | Bdkrb1 | Bkr | Bradykinin B1 receptor | KB1 | Kinin B1 receptor |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 38389.97 |
|---|
| Organism: | RAT |
|---|
| Description: | B1 BRADYKININ BDKRB1 RAT::P97583 |
|---|
| Residue: | 337 |
|---|
| Sequence: | MASEVLLELQPSNRSLQAPANITSCESALEDWDLLYRVLPGFVITICFFGLLGNLLVLSF
FLLPWRQWWWQQRQRQQRLTIAEIYLANLAASDLVFVLGLPFWAENIGNRFNWPFGTDLC
RVVSGVIKANLFVSIFLVVAISQDRYRLLVYPMTSWGYRRRRQAQATCLLIWVAGGLLSI
PTFLLRSVKVVPDLNVSACILLFPHEAWHFARMVELNVLGFLLPVTAIIFFNYHILASLR
GQKEASRTRCGGPKGSKTTGLILTLVASFLVCWCPYHFFAFLDFLVQVRVIQDCSWKEIT
DLGLQLANFFAFVNSCLNPLIYVFAGRLLKTRVLGTL
|
|
|
|---|
| BDBM50370216 |
|---|
| n/a |
|---|
| Name | BDBM50370216 |
|---|
| Synonyms: | CHEMBL1744084 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C34H41N7O2 |
|---|
| Mol. Mass. | 579.735 |
|---|
| SMILES | CCCN1c2ccccc2C(=N[C@@H](NC(=O)Nc2ccc(cc2)N2CCN(CC2)c2ccncc2)C1=O)C1CCCCC1 |r,c:11| |
|---|
| Structure | 
|
|---|
Search and Browse
