| Reaction Details |
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 | Report a problem with these data |
| Target | Reverse transcriptase/RNaseH |
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| Ligand | BDBM50127513 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_195507 (CHEMBL798928) |
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| IC50 | 6700±n/a nM |
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| Citation |  Hyde, RM; Broom, AD; Buckheit, RW Antiviral amphipathic oligo- and polyribonucleotides: analogue development and biological studies. J Med Chem46:1878-85 (2003) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Reverse transcriptase/RNaseH |
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| Name: | Reverse transcriptase/RNaseH |
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| Synonyms: | HIV-1 Reverse Transcriptase RNase H | Human immunodeficiency virus type 1 reverse transcriptase | Reverse transcriptase/RNaseH |
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| Type: | PROTEIN |
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| Mol. Mass.: | 65229.15 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | ChEMBL_1473730 |
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| Residue: | 566 |
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| Sequence: | PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLVSAGIRKVLFLDGID
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| BDBM50127513 |
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| n/a |
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| Name | BDBM50127513 |
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| Synonyms: | (2R,3S,5R)-4-methoxy-2-(methoxymethyl)-5-(6-oxo-1-propyl-6,9-dihydro-1H-purin-9-yl)oxolan-3-yl methylphosphonate | oligonucleotide |
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| Type | Small organic molecule |
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| Emp. Form. | C16H24N4O7P |
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| Mol. Mass. | 415.3587 |
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| SMILES | CCCn1cnc2n(cnc2c1=O)[C@@H]1O[C@H](COC)[C@H](OP(C)([O-])=O)C1OC |
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| Structure | 
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