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TargetSteroid 17-alpha-hydroxylase/17,20 lyase
LigandBDBM50097370
Substrate/Competitorn/a
Meas. Tech.ChEMBL_50520 (CHEMBL661137)
IC50 42±n/a nM
Citation Clement, OOFreeman, CMHartmann, RWHandratta, VDVasaitis, TSBrodie, AMNjar, VC Three dimensional pharmacophore modeling of human CYP17 inhibitors. Potential agents for prostate cancer therapy. J Med Chem46:2345-51 (2003) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Steroid 17-alpha-hydroxylase/17,20 lyase
Name:Steroid 17-alpha-hydroxylase/17,20 lyase
Synonyms:CP17A_HUMAN | CYP17 | CYP17A1 | CYPXVII | Cytochrome P450 17A1 | Cytochrome P450 C17 (CYP17 ) | Cytochrome P450 C17 (CYP17) | Cytochrome P450 CYP17 | Cytochrome P450-C17 | Cytochrome P450-C17 (CYP17) | P450-C17 | S17AH | Steroid 17-alpha-Monooxygenase (CYP17) | Steroid 17-alpha-hydroxylase/17,20 lyase | Steroid 17-alpha-monooxygenase | cytochrome P450 monooxygenase 17 alpha hydroxylase/17,20-lyase (CYP17)
Type:Enzyme
Mol. Mass.:57382.42
Organism:Homo sapiens (Human)
Description:E.coli expressing human CYP17
Residue:508
Sequence:
MWELVALLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKY
GPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAH
WQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVIS
LICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRN
DLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIF
GAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREV
LRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNP
AGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIP
KVVFLIDSFKVKIKVRQAWREAQAEGST
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50097370
n/a
NameBDBM50097370
Synonyms:1-((1H-imidazol-1-yl)methyl)-4-bromo-9H-xanthen-9-one | 4-Bromo-1-imidazol-1-ylmethyl-xanthen-9-one | CHEMBL78322
TypeSmall organic molecule
Emp. Form.C17H11BrN2O2
Mol. Mass.355.185
SMILESBrc1ccc(Cn2ccnc2)c2c1oc1ccccc1c2=O
Structure
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