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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Steroid 17-alpha-hydroxylase/17,20 lyase | ||
| Ligand | BDBM50215709 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_50527 (CHEMBL661144) | ||
| IC50 | 56±n/a nM | ||
| Citation |  Clement, OO; Freeman, CM; Hartmann, RW; Handratta, VD; Vasaitis, TS; Brodie, AM; Njar, VC Three dimensional pharmacophore modeling of human CYP17 inhibitors. Potential agents for prostate cancer therapy. J Med Chem46:2345-51 (2003) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Steroid 17-alpha-hydroxylase/17,20 lyase | |||
| Name: | Steroid 17-alpha-hydroxylase/17,20 lyase | ||
| Synonyms: | CP17A_HUMAN | CYP17 | CYP17A1 | CYPXVII | Cytochrome P450 17A1 | Cytochrome P450 C17 (CYP17 ) | Cytochrome P450 C17 (CYP17) | Cytochrome P450 CYP17 | Cytochrome P450-C17 | Cytochrome P450-C17 (CYP17) | P450-C17 | S17AH | Steroid 17-alpha-Monooxygenase (CYP17) | Steroid 17-alpha-hydroxylase/17,20 lyase | Steroid 17-alpha-monooxygenase | cytochrome P450 monooxygenase 17 alpha hydroxylase/17,20-lyase (CYP17) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 57382.42 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | E.coli expressing human CYP17 | ||
| Residue: | 508 | ||
| Sequence: |
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| BDBM50215709 | |||
| n/a | |||
| Name | BDBM50215709 | ||
| Synonyms: | CHEMBL1170 | Propionic acid (8R,9S,10R,13S,14S,17S)-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl ester | Propionic acid 10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl ester | Propionic acid 10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl ester(Testosterone Propionate) | TESTOSTERONE PROPIONATE | testosteron propionate | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H32O3 | ||
| Mol. Mass. | 344.4877 | ||
| SMILES | CCC(=O)O[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C |r,t:12| | ||
| Structure | 
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