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TargetInterstitial collagenase
LigandBDBM50128637
Substrate/Competitorn/a
Meas. Tech.ChEMBL_106291 (CHEMBL714547)
IC50 494±n/a nM
Citation Aranapakam, VDavis, JMGrosu, GTBaker, JEllingboe, JZask, ALevin, JISandanayaka, VPDu, MSkotnicki, JSDiJoseph, JFSung, ASharr, MAKillar, LMWalter, TJin, GCowling, RTillett, JZhao, WMcDevitt, JXu, ZB Synthesis and structure-activity relationship of N-substituted 4-arylsulfonylpiperidine-4-hydroxamic acids as novel, orally active matrix metalloproteinase inhibitors for the treatment of osteoarthritis. J Med Chem46:2376-96 (2003) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Interstitial collagenase
Name:Interstitial collagenase
Synonyms:CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1)
Type:Enzyme
Mol. Mass.:54010.26
Organism:Homo sapiens (Human)
Description: P03956
Residue:469
Sequence:
MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPV
VEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIEN
YTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGN
LAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSY
TFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDR
FYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGY
PKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFP
GIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50128637
n/a
NameBDBM50128637
Synonyms:4-(4-Methoxy-benzenesulfonyl)-1-(4-methyl-benzyl)-piperidine-4-carboxylic acid hydroxyamide | CHEMBL77176
TypeSmall organic molecule
Emp. Form.C21H26N2O5S
Mol. Mass.418.507
SMILESCOc1ccc(cc1)S(=O)(=O)C1(CCN(Cc2ccc(C)cc2)CC1)C(=O)NO
Structure
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