Reaction Details |
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Target | Delta-type opioid receptor |
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Ligand | BDBM50130601 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_145475 (CHEMBL751262) |
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Ki | 83±n/a nM |
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Citation | Grundt, P; Martinez-Bermejo, F; Lewis, JW; Husbands, SM Opioid binding and in vitro profiles of a series of 4-hdroxy-3-methoxyindolomorphinans. Transformation of a delta-selective ligand into a high affinity kappa-selective ligand by introduction of a 5,14-substituted bridge. J Med Chem46:3174-7 (2003) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Delta-type opioid receptor |
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Name: | Delta-type opioid receptor |
Synonyms: | D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 40382.98 |
Organism: | Homo sapiens (Human) |
Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor. |
Residue: | 372 |
Sequence: | MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVC
AVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELL
CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVG
VPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRL
RSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAAL
HLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTAC
TPSDGPGGGAAA
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BDBM50130601 |
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n/a |
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Name | BDBM50130601 |
Synonyms: | 26-[(E)-ethylidene]-19-methoxy-24-methyl-4,24-diazaheptacyclo[12.7.3.22,13.01,13.03,11.05,10.016,21]hexacosa-3(11),5(10),6,8,16(21),17,19-heptaen-20-ol | CHEMBL320306 |
Type | Small organic molecule |
Emp. Form. | C28H30N2O2 |
Mol. Mass. | 426.55 |
SMILES | COc1ccc2CC3N(C)CC[C@@]4([C@@H]5\C(C[C@]34Cc3c5[nH]c4ccccc34)=C\C)c2c1O |TLB:30:29:16:8.11.10,4:5:16:8.11.10| |
Structure |
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