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TargetLanosterol synthase
LigandBDBM50130774
Substrate/Competitorn/a
Meas. Tech.ChEMBL_80 (CHEMBL615201)
IC50 6.3±n/a nM
Citation Dehmlow, HAebi, JDJolidon, SJi, YHvon der Mark, EMHimber, JMorand, OH Synthesis and structure-activity studies of novel orally active non-terpenoic 2,3-oxidosqualene cyclase inhibitors. J Med Chem46:3354-70 (2003) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Lanosterol synthase
Name:Lanosterol synthase
Synonyms:2,3-epoxysqualene--lanosterol cyclase | LSS | LSS_HUMAN | OSC | Oxidosqualene--lanosterol cyclase
Type:PROTEIN
Mol. Mass.:83309.32
Organism:Homo sapiens (Human)
Description:ChEMBL_11231
Residue:732
Sequence:
MTEGTCLRRRGGPYKTEPATDLGRWRLNCERGRQTWTYLQDERAGREQTGLEAYALGLDT
KNYFKDLPKAHTAFEGALNGMTFYVGLQAEDGHWTGDYGGPLFLLPGLLITCHVARIPLP
AGYREEIVRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVSLRILGVGPDDPDLVRARNIL
HKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCHCRQVYLPM
SYCYAVRLSAAEDPLVQSLRQELYVEDFASIDWLAQRNNVAPDELYTPHSWLLRVVYALL
NLYEHHHSAHLRQRAVQKLYEHIVADDRFTKSISIGPISKTINMLVRWYVDGPASTAFQE
HVSRIPDYLWMGLDGMKMQGTNGSQIWDTAFAIQALLEAGGHHRPEFSSCLQKAHEFLRL
SQVPDNPPDYQKYYRQMRKGGFSFSTLDCGWIVSDCTAEALKAVLLLQEKCPHVTEHIPR
ERLCDAVAVLLNMRNPDGGFATYETKRGGHLLELLNPSEVFGDIMIDYTYVECTSAVMQA
LKYFHKRFPEHRAAEIRETLTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMG
QTYRDGTACAEVSRACDFLLSRQMADGGWGEDFESCEERRYLQSAQSQIHNTCWAMMGLM
AVRHPDIEAQERGVRCLLEKQLPNGDWPQENIAGVFNKSCAISYTSYRNIFPIWALGRFS
QLYPERALAGHP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50130774
n/a
NameBDBM50130774
Synonyms:CHEMBL115375 | CHEMBL611757 | {4-[6-(Allyl-methyl-amino)-hexyloxy]-2-hydroxy-phenyl}-(4-bromo-phenyl)-methanone; fumarate
TypeSmall organic molecule
Emp. Form.C23H28BrNO3
Mol. Mass.446.377
SMILESCN(CCCCCCOc1ccc(C(=O)c2ccc(Br)cc2)c(O)c1)CC=C
Structure
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