Reaction Details |
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Target | Lanosterol synthase |
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Ligand | BDBM50128054 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_80 (CHEMBL615201) |
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IC50 | 3.5±n/a nM |
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Citation | Dehmlow, H; Aebi, JD; Jolidon, S; Ji, YH; von der Mark, EM; Himber, J; Morand, OH Synthesis and structure-activity studies of novel orally active non-terpenoic 2,3-oxidosqualene cyclase inhibitors. J Med Chem46:3354-70 (2003) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Lanosterol synthase |
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Name: | Lanosterol synthase |
Synonyms: | 2,3-epoxysqualene--lanosterol cyclase | LSS | LSS_HUMAN | OSC | Oxidosqualene--lanosterol cyclase |
Type: | PROTEIN |
Mol. Mass.: | 83309.32 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_11231 |
Residue: | 732 |
Sequence: | MTEGTCLRRRGGPYKTEPATDLGRWRLNCERGRQTWTYLQDERAGREQTGLEAYALGLDT
KNYFKDLPKAHTAFEGALNGMTFYVGLQAEDGHWTGDYGGPLFLLPGLLITCHVARIPLP
AGYREEIVRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVSLRILGVGPDDPDLVRARNIL
HKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCHCRQVYLPM
SYCYAVRLSAAEDPLVQSLRQELYVEDFASIDWLAQRNNVAPDELYTPHSWLLRVVYALL
NLYEHHHSAHLRQRAVQKLYEHIVADDRFTKSISIGPISKTINMLVRWYVDGPASTAFQE
HVSRIPDYLWMGLDGMKMQGTNGSQIWDTAFAIQALLEAGGHHRPEFSSCLQKAHEFLRL
SQVPDNPPDYQKYYRQMRKGGFSFSTLDCGWIVSDCTAEALKAVLLLQEKCPHVTEHIPR
ERLCDAVAVLLNMRNPDGGFATYETKRGGHLLELLNPSEVFGDIMIDYTYVECTSAVMQA
LKYFHKRFPEHRAAEIRETLTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMG
QTYRDGTACAEVSRACDFLLSRQMADGGWGEDFESCEERRYLQSAQSQIHNTCWAMMGLM
AVRHPDIEAQERGVRCLLEKQLPNGDWPQENIAGVFNKSCAISYTSYRNIFPIWALGRFS
QLYPERALAGHP
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BDBM50128054 |
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n/a |
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Name | BDBM50128054 |
Synonyms: | Allyl-{6-[1-(4-bromo-phenyl)-isoquinolin-6-yloxy]-hexyl}-methyl-amine | CHEMBL543877 | CHEMBL65024 | N-(6-{[1-(4-BROMOPHENYL)ISOQUINOLIN-6-YL]OXY}HEXYL)-N-METHYLPROP-2-EN-1-AMINE | N-allyl-6-(1-(4-bromophenyl)isoquinolin-6-yloxy)-N-methylhexan-1-aminium |
Type | Small organic molecule |
Emp. Form. | C25H29BrN2O |
Mol. Mass. | 453.415 |
SMILES | CN(CCCCCCOc1ccc2c(nccc2c1)-c1ccc(Br)cc1)CC=C |
Structure |
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