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TargetNH(3)-dependent NAD(+) synthetase
LigandBDBM50370232
Substrate/Competitorn/a
Meas. Tech.ChEMBL_141613
IC50>1000±n/a nM
Citation Velu SECristofoli WAGarcia GJBrouillette CGPierson MCLuan CHDeLucas LJBrouillette WJ Tethered dimers as NAD synthetase inhibitors with antibacterial activity. J Med Chem 46:3371-81 (2003) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
NH(3)-dependent NAD(+) synthetase
Name:NH(3)-dependent NAD(+) synthetase
Synonyms:GSP38 | General stress protein 38 | Spore outgrowth factor B | Sporulation protein outB
Type:PROTEIN
Mol. Mass.:30386.77
Organism:Bacillus subtilis
Description:ChEMBL_141613
Residue:272
Sequence:
MSMQEKIMRELHVKPSIDPKQEIEDRVNFLKQYVKKTGAKGFVLGISGGQDSTLAGRLAQ
LAVESIREEGGDAQFIAVRLPHGTQQDEDDAQLALKFIKPDKSWKFDIKSTVSAFSDQYQ
QETGDQLTDFNKGNVKARTRMIAQYAIGGQEGLLVLGTDHAAEAVTGFFTKYGDGGADLL
PLTGLTKRQGRTLLKELGAPERLYLKEPTADLLDEKPQQSDETELGISYDEIDDYLEGKE
VSAKVSEALEKRYSMTEHKRQVPASMFDDWWK
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  Blast E-value cutoff:
BDBM50370232
n/a
NameBDBM50370232
Synonyms:BA-41166E | L-5103 | RIFAMPIN | Rifadin | Rifampicin
TypeSmall organic molecule
Emp. Form.C43H58N4O12
Mol. Mass.822.9402
SMILESCO[C@H]1\C=C\O[C@@]2(C)Oc3c(C2=O)c2c(O)c(\C=N\N4CCN(C)CC4)c(NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)c(O)c2c(O)c3C |r,c:33,t:3,35|
Structure
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