| Reaction Details |
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 | Report a problem with these data |
| Target | Purine nucleoside phosphorylase |
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| Ligand | BDBM50370256 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_162193 (CHEMBL766712) |
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| Ki | 1.4±n/a nM |
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| Citation |  Evans, GB; Furneaux, RH; Lewandowicz, A; Schramm, VL; Tyler, PC Exploring structure-activity relationships of transition state analogues of human purine nucleoside phosphorylase. J Med Chem46:3412-23 (2003) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Purine nucleoside phosphorylase |
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| Name: | Purine nucleoside phosphorylase |
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| Synonyms: | Inosine phosphorylase | Inosine-guanosine phosphorylase | NP | PNP | PNPH_HUMAN | Purine nucleoside phosphorylase (PNPase) |
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| Type: | Enzyme |
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| Mol. Mass.: | 32119.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 289 |
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| Sequence: | MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRST
VPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGL
NPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQ
MGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSL
ITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS
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| BDBM50370256 |
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| n/a |
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| Name | BDBM50370256 |
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| Synonyms: | CHEMBL541578 |
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| Type | Small organic molecule |
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| Emp. Form. | C11H12F2N4O3 |
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| Mol. Mass. | 286.2348 |
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| SMILES | OC[C@H]1N[C@@H](c2c[nH]c3c2nc[nH]c3=O)C(F)(F)[C@H]1O |r| |
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| Structure | 
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