| Reaction Details |
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 | Report a problem with these data |
| Target | Major prion protein |
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| Ligand | BDBM50015214 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_158887 (CHEMBL760875) |
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| EC50 | 300±n/a nM |
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| Citation |  Vogtherr, M; Grimme, S; Elshorst, B; Jacobs, DM; Fiebig, K; Griesinger, C; Zahn, R Antimalarial drug quinacrine binds to C-terminal helix of cellular prion protein. J Med Chem46:3563-4 (2003) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Major prion protein |
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| Name: | Major prion protein |
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| Synonyms: | ALTPRP | ASCR | CD_antigen=CD230 | PRIO_HUMAN | PRIP | PRNP | PRP | PrP27-30 | PrP33-35C | Prion protein | major prion protein preproprotein |
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| Type: | PROTEIN |
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| Mol. Mass.: | 27671.97 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_158887 |
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| Residue: | 253 |
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| Sequence: | MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQP
HGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGA
VVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCV
NITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPV
ILLISFLIFLIVG
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| BDBM50015214 |
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| n/a |
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| Name | BDBM50015214 |
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| Synonyms: | 6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-methylbutyl)amine | 6-chloro-N-(5-(diethylamino)pentan-2-yl)-2-methoxyacridin-9-amine | CHEMBL7568 | N'-(6-chloro-2-methoxy-acridin-9-yl)-N,N-diethyl-pentane-1,4-diamine | N*4*-(6-Chloro-2-methoxy-acridin-9-yl)-N*1*,N*1*-diethyl-pentane-1,4-diamine | N*4*-(6-Chloro-2-methoxy-acridin-9-yl)-N*1*,N*1*-diethyl-pentane-1,4-diamine (Mepacrine) | N*4*-(6-Chloro-2-methoxy-acridin-9-yl)-N*1*,N*1*-diethyl-pentane-1,4-diamine ; (mepacrine) | N-(4-Hydroxy-phenyl)-acetamide | cid_237 | quinacrine |
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| Type | Small organic molecule |
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| Emp. Form. | C23H30ClN3O |
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| Mol. Mass. | 399.957 |
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| SMILES | CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12 |
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| Structure | 
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