Reaction Details |
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Target | Serine protease 1/Trypsin-2 |
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Ligand | BDBM50131780 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_212564 (CHEMBL814922) |
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Ki | 0.3±n/a nM |
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Citation | Lee, K; Park, CW; Jung, WH; Park, HD; Lee, SH; Chung, KH; Park, SK; Kwon, OH; Kang, M; Park, DH; Lee, SK; Kim, EE; Yoon, SK; Kim, A Efficacious and orally bioavailable thrombin inhibitors based on a 2,5-thienylamidine at the P1 position: discovery of N-carboxymethyl-d-diphenylalanyl-l-prolyl[(5-amidino-2-thienyl)methyl]amide. J Med Chem46:3612-22 (2003) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Serine protease 1/Trypsin-2 |
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Name: | Serine protease 1/Trypsin-2 |
Synonyms: | Trypsin II |
Type: | n/a |
Mol. Mass.: | n/a |
Description: | ASSAY_ID of EBI is 212335 |
Components: | This complex has 2 components. |
Component 1 |
Name: | Serine protease 1 |
Synonyms: | Alpha-trypsin chain 1 | Alpha-trypsin chain 2 | Beta-trypsin | Cationic trypsinogen | PRSS1 | Serine protease 1 | TRP1 | TRY1 | TRY1_HUMAN | TRYP1 | Thrombin & trypsin | Trypsin | Trypsin I | Trypsin-1 |
Type: | Enzyme |
Mol. Mass.: | 26557.80 |
Organism: | Homo sapiens (Human) |
Description: | P07477 |
Residue: | 247 |
Sequence: | MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVS
AGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVIN
ARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKIT
SNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIK
NTIAANS
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Component 2 |
Name: | Trypsin-2 |
Synonyms: | Anionic trypsinogen | PRSS2 | Serine protease 2 | TRY2 | TRY2_HUMAN | TRYP2 | Thrombin & trypsin | Trypsin | Trypsin II | Trypsin-2 |
Type: | PROTEIN |
Mol. Mass.: | 26479.43 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_41517 |
Residue: | 247 |
Sequence: | MNLLLILTFVAAAVAAPFDDDDKIVGGYICEENSVPYQVSLNSGYHFCGGSLISEQWVVS
AGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPKYNSRTLDNDILLIKLSSPAVIN
SRVSAISLPTAPPAAGTESLISGWGNTLSSGADYPDELQCLDAPVLSQAECEASYPGKIT
NNMFCVGFLEGGKDSCQGDSGGPVVSNGELQGIVSWGYGCAQKNRPGVYTKVYNYVDWIK
DTIAANS
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BDBM50131780 |
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n/a |
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Name | BDBM50131780 |
Synonyms: | (1-Benzhydryl-2-{2-[(5-carbamimidoyl-thiophen-2-ylmethyl)-carbamoyl]-pyrrolidin-1-yl}-2-oxo-ethylamino)-acetic acid | CHEMBL420540 |
Type | Small organic molecule |
Emp. Form. | C28H31N5O4S |
Mol. Mass. | 533.642 |
SMILES | NC(=N)c1ccc(CNC(=O)[C@@H]2CCCN2C(=O)[C@H](NCC(O)=O)C(c2ccccc2)c2ccccc2)s1 |
Structure |
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