| Reaction Details |
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 | Report a problem with these data |
| Target | Potassium voltage-gated channel subfamily KQT member 2 |
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| Ligand | BDBM50131898 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_158551 (CHEMBL768694) |
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| EC50 | 1550±n/a nM |
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| Citation |  Wu, YJ; Davis, CD; Dworetzky, S; Fitzpatrick, WC; Harden, D; He, H; Knox, RJ; Newton, AE; Philip, T; Polson, C; Sivarao, DV; Sun, LQ; Tertyshnikova, S; Weaver, D; Yeola, S; Zoeckler, M; Sinz, MW Fluorine substitution can block CYP3A4 metabolism-dependent inhibition: identification of (S)-N-[1-(4-fluoro-3- morpholin-4-ylphenyl)ethyl]-3- (4-fluorophenyl)acrylamide as an orally bioavailable KCNQ2 opener devoid of CYP3A4 metabolism-dependent inhibition. J Med Chem46:3778-81 (2003) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Potassium voltage-gated channel subfamily KQT member 2 |
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| Name: | Potassium voltage-gated channel subfamily KQT member 2 |
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| Synonyms: | KCNQ (Kv7) potassium channel | KCNQ2 | KCNQ2_HUMAN | KQT-like 2 | Neuroblastoma-specific potassium channel subunit alpha KvLQT2 | Potassium voltage-gated channel subfamily KQT member 2 | Voltage-gated potassium channel subunit Kv7.2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 95883.20 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1457496 |
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| Residue: | 872 |
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| Sequence: | MVQKSRNGGVYPGPSGEKKLKVGFVGLDPGAPDSTRDGALLIAGSEAPKRGSILSKPRAG
GAGAGKPPKRNAFYRKLQNFLYNVLERPRGWAFIYHAYVFLLVFSCLVLSVFSTIKEYEK
SSEGALYILEIVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASI
AVLAAGSQGNVFATSALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGF
LCLILASFLVYLAEKGENDHFDTYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLI
GVSFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAAGLIQSAWRFYATNLSRTDLHSTW
QYYERTVTVPMYSSQTQTYGASRLIPPLNQLELLRNLKSKSGLAFRKDPPPEPSPSKGSP
CRGPLCGCCPGRSSQKVSLKDRVFSSPRGVAAKGKGSPQAQTVRRSPSADQSLEDSPSKV
PKSWSFGDRSRARQAFRIKGAASRQNSEEASLPGEDIVDDKSCPCEFVTEDLTPGLKVSI
RAVCVMRFLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQSRVDQIVGRGPAIT
DKDRTKGPAEAELPEDPSMMGRLGKVEKQVLSMEKKLDFLVNIYMQRMGIPPTETEAYFG
AKEPEPAPPYHSPEDSREHVDRHGCIVKIVRSSSSTGQKNFSAPPAAPPVQCPPSTSWQP
QSHPRQGHGTSPVGDHGSLVRIPPPPAHERSLSAYGGGNRASMEFLRQEDTPGCRPPEGN
LRDSDTSISIPSVDHEELERSFSGFSISQSKENLDALNSCYAAVAPCAKVRPYIAEGESD
TDSDLCTPCGPPPRSATGEGPFGDVGWAGPRK
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| BDBM50131898 |
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| n/a |
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| Name | BDBM50131898 |
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| Synonyms: | (E)-N-[1-((S)-4-Fluoro-3-morpholin-4-yl-phenyl)-ethyl]-3-(4-fluoro-phenyl)-acrylamide | (S,E)-N-(1-(4-fluoro-3-morpholinophenyl)ethyl)-3-(4-fluorophenyl)acrylamide | CHEMBL100379 | N-[1-(4-Fluoro-3-morpholin-4-yl-phenyl)-ethyl]-3-(4-fluoro-phenyl)-acrylamide |
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| Type | Small organic molecule |
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| Emp. Form. | C21H22F2N2O2 |
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| Mol. Mass. | 372.4084 |
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| SMILES | C[C@H](NC(=O)\C=C\c1ccc(F)cc1)c1ccc(F)c(c1)N1CCOCC1 |
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| Structure | 
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