Reaction Details |
| Report a problem with these data |
Target | Thymidylate kinase |
---|
Ligand | BDBM50118627 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_208211 (CHEMBL873990) |
---|
Ki | 27000±n/a nM |
---|
Citation | Vanheusden, V; Munier-Lehmann, H; Froeyen, M; Dugué, L; Heyerick, A; De Keukeleire, D; Pochet, S; Busson, R; Herdewijn, P; Van Calenbergh, S 3'-C-branched-chain-substituted nucleosides and nucleotides as potent inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase. J Med Chem46:3811-21 (2003) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Thymidylate kinase |
---|
Name: | Thymidylate kinase |
Synonyms: | KTHY_MYCTU | TMPK | Thymidine monophosphate kinase | dTMP kinase | tmk |
Type: | PROTEIN |
Mol. Mass.: | 22636.29 |
Organism: | Mycobacterium tuberculosis |
Description: | ChEMBL_208218 |
Residue: | 214 |
Sequence: | MLIAIEGVDGAGKRTLVEKLSGAFRAAGRSVATLAFPRYGQSVAADIAAEALHGEHGDLA
SSVYAMATLFALDRAGAVHTIQGLCRGYDVVILDRYVASNAAYSAARLHENAAGKAAAWV
QRIEFARLGLPKPDWQVLLAVSAELAGERSRGRAQRDPGRARDNYERDAELQQRTGAVYA
ELAAQGWGGRWLVVGADVDPGRLAATLAPPDVPS
|
|
|
BDBM50118627 |
---|
n/a |
---|
Name | BDBM50118627 |
Synonyms: | (R)-1-((R)-4-Amino-3-hydroxy-5-methylphosphate-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione | Phosphoric acid mono-[3-amino-4-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl] ester |
Type | Small organic molecule |
Emp. Form. | C10H14N3O8P |
Mol. Mass. | 335.2083 |
SMILES | Cc1cn([C@@H]2O[C@H](COP([O-])([O-])=O)[C@@H](N)[C@H]2O)c(=O)[nH]c1=O |
Structure |
|