| Reaction Details |
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 | Report a problem with these data |
| Target | Thymidylate kinase |
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| Ligand | BDBM50131919 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_208211 (CHEMBL873990) |
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| Ki | 770000±n/a nM |
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| Citation |  Vanheusden, V; Munier-Lehmann, H; Froeyen, M; Dugué, L; Heyerick, A; De Keukeleire, D; Pochet, S; Busson, R; Herdewijn, P; Van Calenbergh, S 3'-C-branched-chain-substituted nucleosides and nucleotides as potent inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase. J Med Chem46:3811-21 (2003) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Thymidylate kinase |
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| Name: | Thymidylate kinase |
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| Synonyms: | KTHY_MYCTU | TMPK | Thymidine monophosphate kinase | dTMP kinase | tmk |
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| Type: | PROTEIN |
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| Mol. Mass.: | 22636.29 |
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| Organism: | Mycobacterium tuberculosis |
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| Description: | ChEMBL_208218 |
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| Residue: | 214 |
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| Sequence: | MLIAIEGVDGAGKRTLVEKLSGAFRAAGRSVATLAFPRYGQSVAADIAAEALHGEHGDLA
SSVYAMATLFALDRAGAVHTIQGLCRGYDVVILDRYVASNAAYSAARLHENAAGKAAAWV
QRIEFARLGLPKPDWQVLLAVSAELAGERSRGRAQRDPGRARDNYERDAELQQRTGAVYA
ELAAQGWGGRWLVVGADVDPGRLAATLAPPDVPS
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| BDBM50131919 |
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| n/a |
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| Name | BDBM50131919 |
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| Synonyms: | 1-(4-Azidomethyl-3-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione | CHEMBL123912 |
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| Type | Small organic molecule |
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| Emp. Form. | C11H15N5O5 |
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| Mol. Mass. | 297.2673 |
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| SMILES | Cc1cn([C@@H]2O[C@H](CO)[C@@H](CN=[N+]=[N-])[C@H]2O)c(=O)[nH]c1=O |
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| Structure | 
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