| Reaction Details |
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 | Report a problem with these data |
| Target | Alpha-2A adrenergic receptor [16-465] |
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| Ligand | BDBM50131926 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_33298 (CHEMBL646151) |
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| Ki | 76±n/a nM |
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| Citation |  Campiani, G; Butini, S; Trotta, F; Fattorusso, C; Catalanotti, B; Aiello, F; Gemma, S; Nacci, V; Novellino, E; Stark, JA; Cagnotto, A; Fumagalli, E; Carnovali, F; Cervo, L; Mennini, T Synthesis and pharmacological evaluation of potent and highly selective D3 receptor ligands: inhibition of cocaine-seeking behavior and the role of dopamine D3/D2 receptors. J Med Chem46:3822-39 (2003) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Alpha-2A adrenergic receptor [16-465] |
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| Name: | Alpha-2A adrenergic receptor [16-465] |
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| Synonyms: | ADA2A_RAT | Adra2a | Adrenaline 2 | Alpha-2A adrenergic receptor | Alpha-2A adrenoceptor | Alpha-2A adrenoreceptor | Alpha-2AAR | Alpha-2D adrenergic receptor | Alpha2 Adrenoreceptor | CA2-47 | adrenergic Alpha2A |
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| Type: | G-protein coupled receptor |
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| Mol. Mass.: | 48961.69 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | P22909[16-465] |
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| Residue: | 450 |
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| Sequence: | MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFT
SRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSS
IVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGG
QQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACS
APPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSE
HAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKAS
RWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSS
LNPVIYTIFNHDFRRAFKKILCRGDRKRIV
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| BDBM50131926 |
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| n/a |
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| Name | BDBM50131926 |
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| Synonyms: | CHEMBL127400 | CHEMBL129022 | Isoquinoline-3-carboxylic acid {4-[4-(2-methoxy-phenyl)-piperazin-1-yl]-butyl}-amide |
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| Type | Small organic molecule |
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| Emp. Form. | C25H30N4O2 |
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| Mol. Mass. | 418.5313 |
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| SMILES | COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3cn2)CC1 |
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| Structure | 
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