| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-lactamase |
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| Ligand | BDBM50065297 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_40260 (CHEMBL877274) |
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| IC50 | 6000±n/a nM |
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| Citation |  McGovern, SL; Helfand, BT; Feng, B; Shoichet, BK A specific mechanism of nonspecific inhibition. J Med Chem46:4265-72 (2003) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Beta-lactamase |
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| Name: | Beta-lactamase |
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| Synonyms: | AMPC_ECOLI | Beta-lactamase | Beta-lactamase (AmpC) | Beta-lactamase AmpC | Cephalosporinase | Escherichia coli K-12 | ampA | ampC |
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| Type: | Protien |
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| Mol. Mass.: | 41561.62 |
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| Organism: | Escherichia coli |
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| Description: | P00811 |
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| Residue: | 377 |
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| Sequence: | MFKTTLCALLITASCSTFAAPQQINDIVHRTITPLIEQQKIPGMAVAVIYQGKPYYFTWG
YADIAKKQPVTQQTLFELGSVSKTFTGVLGGDAIARGEIKLSDPTTKYWPELTAKQWNGI
TLLHLATYTAGGLPLQVPDEVKSSSDLLRFYQNWQPAWAPGTQRLYANSSIGLFGALAVK
PSGLSFEQAMQTRVFQPLKLNHTWINVPPAEEKNYAWGYREGKAVHVSPGALDAEAYGVK
STIEDMARWVQSNLKPLDINEKTLQQGIQLAQSRYWQTGDMYQGLGWEMLDWPVNPDSII
NGSDNKIALAARPVKAITPPTPAVRASWVHKTGATGGFGSYVAFIPEKELGIVMLANKNY
PNPARVDAAWQILNALQ
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|
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| BDBM50065297 |
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| n/a |
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| Name | BDBM50065297 |
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| Synonyms: | 3-(4-Isopropyl-benzylidene)-1,3-dihydro-indol-2-one | 3-[1-(4-Isopropyl-phenyl)-meth-(E)-ylidene]-1,3-dihydro-indol-2-one | CHEMBL48760 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H17NO |
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| Mol. Mass. | 263.3337 |
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| SMILES | CC(C)c1ccc(\C=C2\C(=O)Nc3ccccc23)cc1 |
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| Structure | 
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