| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Malate dehydrogenase, cytoplasmic |
|---|
| Ligand | BDBM50367298 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_104019 (CHEMBL709628) |
|---|
| IC50 | 50000±n/a nM |
|---|
| Citation |  Seidler, J; McGovern, SL; Doman, TN; Shoichet, BK Identification and prediction of promiscuous aggregating inhibitors among known drugs. J Med Chem46:4477-86 (2003) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Malate dehydrogenase, cytoplasmic |
|---|
| Name: | Malate dehydrogenase, cytoplasmic |
|---|
| Synonyms: | Cytosolic malate dehydrogenase | MDH1 | MDHA | MDHC_HUMAN | Malate dehydrogenase cytoplasmic | Malate dehydrogenase, cytoplasmic |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 36427.72 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1456624 |
|---|
| Residue: | 334 |
|---|
| Sequence: | MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDC
ALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYA
KKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKN
VIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKL
SSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFV
EGLPINDFSREKMDLTAKELTEEKESAFEFLSSA
|
|
|
|---|
| BDBM50367298 |
|---|
| n/a |
|---|
| Name | BDBM50367298 |
|---|
| Synonyms: | Cardene | NICARDIPINE |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H29N3O6 |
|---|
| Mol. Mass. | 479.525 |
|---|
| SMILES | COC(=O)C1C(C(C(=O)OCCN(C)Cc2ccccc2)=C(C)N=C1C)c1cccc(c1)[N+]([O-])=O |c:24,t:21| |
|---|
| Structure | 
|
|---|
Search and Browse
