| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 3A/3B |
|---|
| Ligand | BDBM48320 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_3234 (CHEMBL618920) |
|---|
| Ki | 210±n/a nM |
|---|
| Citation |  Hirokawa, Y; Fujiwara, I; Suzuki, K; Harada, H; Yoshikawa, T; Yoshida, N; Kato, S Synthesis and structure-affinity relationships of novel N-(1-ethyl-4-methylhexahydro-1,4-diazepin-6-yl)pyridine-3-carboxamides with potent serotonin 5-HT3 and dopamine D2 receptor antagonistic activity. J Med Chem46:702-15 (2003) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| 5-hydroxytryptamine receptor 3A/3B |
|---|
| Name: | 5-hydroxytryptamine receptor 3A/3B |
|---|
| Synonyms: | Serotonin 3 (5-HT3) receptor | Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | n/a |
|---|
| Description: | ASSAY_ID of EBI is 2974 |
|---|
| Components: | This complex has 2 components. |
|---|
| Component 1 |
| Name: | 5-hydroxytryptamine receptor 3B |
|---|
| Synonyms: | 5HT3B_RAT | Htr3b | Serotonin (5-HT) receptor |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 50328.78 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | EBI_11885 |
|---|
| Residue: | 437 |
|---|
| Sequence: | MILLWSCLLVAVVGILGTATPQPGNSSLHRLTRQLLQQYHKEVRPVYNWAEATTVYLDLC
VHAVLDVDVQNQKLKTSMWYREVWNDEFLSWNSSLFDDIQEISLPLSAIWAPDIIINEFV
DVERSPDLPYVYVNSSGTIRNHKPIQVVSACSLQTYAFPFDIQNCSLTFNSILHTVEDID
LGFLRNQEDIENDKRSFLNDSEWQLLSVTSTYHIRQSSAGDFAQIRFNVVIRRCPLAYVV
SLLIPSIFLMLVDLGSFYLPPNCRARIVFKTNVLVGYTVFRVNMSDEVPRSAGCTSLIGV
FFTVCMALLVLSLSKSILLIKFLYEERHSEQERPLMCLRGDSDANESRLYLRAPCAEDTE
SPVRQEHQVPSDTLKDFWFQLQSINNSLRTRDQVYQKEVEWLAILCHFDQLLFRIYLAVL
GLYTVTLCSLWALWSRM
|
|
|
|---|
| Component 2 |
| Name: | 5-hydroxytryptamine receptor 3A |
|---|
| Synonyms: | 5-HT3 | 5-hydroxytryptamine receptor 3A | 5HT3A_RAT | 5ht3 | Htr3 | Htr3a | Serotonin (5-HT) receptor | Zacopride site-R |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 55428.70 |
|---|
| Organism: | RAT |
|---|
| Description: | 5-HT3 HTR3A RAT::P35563 |
|---|
| Residue: | 483 |
|---|
| Sequence: | MPLCIPQVLLALFLSVLIAQGEGSRRRATQAHSTTQPALLRLSDHLLANYKKGVRPVRDW
RKPTLVSIDVIMYAILNVDEKNQVLTTYIWYRQFWTDEFLQWTPEDFDNVTKLSIPTDSI
WVPDILINEFVDVGKSPSIPYVYVHHQGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTF
TSWLHTIQDINISLWRTPEEVRSDKSIFINQGEWELLGVFTKFQEFSIETSNSYAEMKFY
VVIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTL
PATAIGTPLIGVYFVVCMALLVISLAETIFIVQLVHKQDLQRPVPDWLRHLVLDRIAWLL
CLGEQPMAHRPPATFQANKTDDCSAMGNHCSHVGSPQDLEKTSRSRDSPLPPPREASLAV
RGLLQELSSIRHSLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIW
HYS
|
|
|
|---|
| BDBM48320 |
|---|
| n/a |
|---|
| Name | BDBM48320 |
|---|
| Synonyms: | 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxy-benzamide;hydrochloride | 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide;hydrochloride | 4-azanyl-5-chloranyl-N-[2-(diethylamino)ethyl]-2-methoxy-benzamide;hydrochloride | METOCLOPRAMIDE | METOCLOPRAMIDE HYDROCHLORIDE | MLS000069667 | Metochloropramide | SMR000058471 | US11147820, Compound Metoclopramide | US11717500, Compound Metoclopramide | US9132134, Metoclopramide | cid_23659 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C14H22ClN3O2 |
|---|
| Mol. Mass. | 299.796 |
|---|
| SMILES | CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OC |
|---|
| Structure | 
|
|---|
Search and Browse
