| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Acetylcholine receptor subunit alpha/beta/delta/gamma |
|---|
| Ligand | BDBM50125936 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_144958 (CHEMBL755076) |
|---|
| IC50 | 23000±n/a nM |
|---|
| Citation |  Husain, SS; Ziebell, MR; Ruesch, D; Hong, F; Arevalo, E; Kosterlitz, JA; Olsen, RW; Forman, SA; Cohen, JB; Miller, KW 2-(3-Methyl-3H-diaziren-3-yl)ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate: a derivative of the stereoselective general anesthetic etomidate for photolabeling ligand-gated ion channels. J Med Chem46:1257-65 (2003) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Acetylcholine receptor subunit alpha/beta/delta/gamma |
|---|
| Name: | Acetylcholine receptor subunit alpha/beta/delta/gamma |
|---|
| Synonyms: | Acetylcholine receptor | Acetylcholine receptor protein alpha/beta/delta/gamma chain |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | n/a |
|---|
| Description: | ASSAY_ID of EBI is 143080 |
|---|
| Components: | This complex has 4 components. |
|---|
| Component 1 |
| Name: | Acetylcholine receptor subunit beta |
|---|
| Synonyms: | ACHB_TETCF | Acetylcholine receptor | CHRNB1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 56146.98 |
|---|
| Organism: | Torpedo californica |
|---|
| Description: | EBI_19626 |
|---|
| Residue: | 493 |
|---|
| Sequence: | MENVRRMALGLVVMMALALSGVGASVMEDTLLSVLFETYNPKVRPAQTVGDKVTVRVGLT
LTNLLILNEKIEEMTTNVFLNLAWTDYRLQWDPAAYEGIKDLRIPSSDVWQPDIVLMNNN
DGSFEITLHVNVLVQHTGAVSWQPSAIYRSSCTIKVMYFPFDWQNCTMVFKSYTYDTSEV
TLQHALDAKGEREVKEIVINKDAFTENGQWSIEHKPSRKNWRSDDPSYEDVTFYLIIQRK
PLFYIVYTIIPCILISILAILVFYLPPDAGEKMSLSISALLAVTVFLLLLADKVPETSLS
VPIIIRYLMFIMILVAFSVILSVVVLNLHHRSPNTHTMPNWIRQIFIETLPPFLWIQRPV
TTPSPDSKPTIISRANDEYFIRKPAGDFVCPVDNARVAVQPERLFSEMKWHLNGLTQPVT
LPQDLKEAVEAIKYIAEQLESASEFDDLKKDWQYVAMVADRLFLYVFFVICSIGTFSIFL
DASHNVPPDNPFA
|
|
|
|---|
| Component 2 |
| Name: | Acetylcholine receptor subunit gamma |
|---|
| Synonyms: | ACHG_TETCF | Acetylcholine receptor | CHRNG |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 58151.68 |
|---|
| Organism: | Torpedo californica |
|---|
| Description: | EBI_19662 |
|---|
| Residue: | 506 |
|---|
| Sequence: | MVLTLLLIICLALEVRSENEEGRLIEKLLGDYDKRIIPAKTLDHIIDVTLKLTLTNLISL
NEKEEALTTNVWIEIQWNDYRLSWNTSEYEGIDLVRIPSELLWLPDVVLENNVDGQFEVA
YYANVLVYNDGSMYWLPPAIYRSTCPIAVTYFPFDWQNCSLVFRSQTYNAHEVNLQLSAE
EGEAVEWIHIDPEDFTENGEWTIRHRPAKKNYNWQLTKDDTDFQEIIFFLIIQRKPLFYI
INIIAPCVLISSLVVLVYFLPAQAGGQKCTLSISVLLAQTIFLFLIAQKVPETSLNVPLI
GKYLIFVMFVSMLIVMNCVIVLNVSLRTPNTHSLSEKIKHLFLGFLPKYLGMQLEPSEET
PEKPQPRRRSSFGIMIKAEEYILKKPRSELMFEEQKDRHGLKRVNKMTSDIDIGTTVDLY
KDLANFAPEIKSCVEACNFIAKSTKEQNDSGSENENWVLIGKVIDKACFWIALLLFSIGT
LAIFLTGHFNQVPEFPFPGDPRKYVP
|
|
|
|---|
| Component 3 |
| Name: | Acetylcholine receptor subunit alpha |
|---|
| Synonyms: | ACHA_TETCF | Acetylcholine receptor | Acetylcholine receptor protein alpha chain | CHRNA1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 52735.09 |
|---|
| Organism: | Torpedo californica |
|---|
| Description: | ChEMBL_216981 |
|---|
| Residue: | 461 |
|---|
| Sequence: | MILCSYWHVGLVLLLFSCCGLVLGSEHETRLVANLLENYNKVIRPVEHHTHFVDITVGLQ
LIQLISVDEVNQIVETNVRLRQQWIDVRLRWNPADYGGIKKIRLPSDDVWLPDLVLYNNA
DGDFAIVHMTKLLLDYTGKIMWTPPAIFKSYCEIIVTHFPFDQQNCTMKLGIWTYDGTKV
SISPESDRPDLSTFMESGEWVMKDYRGWKHWVYYTCCPDTPYLDITYHFIMQRIPLYFVV
NVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGK
YMLFTMIFVISSIIITVVVINTHHRSPSTHTMPQWVRKIFIDTIPNVMFFSTMKRASKEK
QENKIFADDIDISDISGKQVTGEVIFQTPLIKNPDVKSAIEGVKYIAEHMKSDEESSNAA
EEWKYVAMVIDHILLCVFMLICIIGTVSVFAGRLIELSQEG
|
|
|
|---|
| Component 4 |
| Name: | Acetylcholine receptor subunit delta |
|---|
| Synonyms: | ACHD_TETCF | Acetylcholine receptor | Acetylcholine receptor protein delta chain | chrnd |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 59885.01 |
|---|
| Organism: | Torpedo californica |
|---|
| Description: | ChEMBL_142744 |
|---|
| Residue: | 522 |
|---|
| Sequence: | MGNIHFVYLLISCLYYSGCSGVNEEERLINDLLIVNKYNKHVRPVKHNNEVVNIALSLTL
SNLISLKETDETLTSNVWMDHAWYDHRLTWNASEYSDISILRLPPELVWIPDIVLQNNND
GQYHVAYFCNVLVRPNGYVTWLPPAIFRSSCPINVLYFPFDWQNCSLKFTALNYDANEIT
MDLMTDTIDGKDYPIEWIIIDPEAFTENGEWEIIHKPAKKNIYPDKFPNGTNYQDVTFYL
IIRRKPLFYVINFITPCVLISFLASLAFYLPAESGEKMSTAISVLLAQAVFLLLTSQRLP
ETALAVPLIGKYLMFIMSLVTGVIVNCGIVLNFHFRTPSTHVLSTRVKQIFLEKLPRILH
MSRADESEQPDWQNDLKLRRSSSVGYISKAQEYFNIKSRSELMFEKQSERHGLVPRVTPR
IGFGNNNENIAASDQLHDEIKSGIDSTNYIVKQIKEKNAYDEEVGNWNLVGQTIDRLSMF
IITPVMVLGTIFIFVMGNFNHPPAKPFEGDPFDYSSDHPRCA
|
|
|
|---|
| BDBM50125936 |
|---|
| n/a |
|---|
| Name | BDBM50125936 |
|---|
| Synonyms: | 3-((R)-1-Phenyl-ethyl)-3H-imidazole-4-carboxylic acid 2-(3-methyl-3H-diazirin-3-yl)-ethyl ester | CHEMBL23497 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H18N4O2 |
|---|
| Mol. Mass. | 298.3397 |
|---|
| SMILES | n/a |
|---|
| Structure | 
|
|---|
Search and Browse
