Ki Summary

Reaction Details

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Target

Malate dehydrogenase

Ligand

BDBM50072147

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_103875 (CHEMBL712992)

IC50

100000±n/a nM

Citation

McGovern, SL; Shoichet, BK Kinase inhibitors: not just for kinases anymore. J Med Chem46:1478-83 (2003) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Malate dehydrogenase

Name:

Malate dehydrogenase

Synonyms:

MDH_THETH | mdh

Type:

PROTEIN

Mol. Mass.:

35423.44

Organism:

Thermus thermophilus

Description:

ChEMBL_1448377

Residue:

327

Sequence:

MKAPVRVAVTGAAGQIGYSLLFRIAAGEMLGKDQPVILQLLEIPQAMKALEGVVMELEDC
AFPLLAGLEATDDPKVAFKDADYALLVGAAPRKAGMERRDLLQVNGKIFTEQGRALAEVA
KKDVKVLVVGNPANTNALIAYKNAPGLNPRNFTAMTRLDHNRAKAQLAKKTGTGVDRIRR
MTVWGNHSSTMFPDLFHAEVDGRPALELVDMEWYEKVFIPTVAQRGAAIIQARGASSAAS
AANAAIEHIRDWALGTPEGDWVSMAVPSQGEYGIPEGIVYSFPVTAKDGAYRVVEGLEIN
EFARKRMEITAQELLDEMEQVKALGLI

BDBM50072147

n/a

Name

BDBM50072147

Synonyms:

(2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)succinonitrile | 1,4-diamino-2,3-dicyano-1,4-bis(2-aminophenylthio)butadiene | 1,4-diamino-2,3-dicyano-1,4-bis[2-aminophenylthio]butadiene monoethanolate | 2,3-Bis-[1-amino-1-(2-amino-phenylsulfanyl)-meth-(Z)-ylidene]-succinonitrile | 2,3-Bis-[amino-(2-amino-phenylsulfanyl)-methylene]-succinonitrile | 2,3-bis(amino(2-aminophenylthio)methylene)succinonitrile | 2-[1-Amino-1-(2-amino-phenylsulfanyl)-meth-(Z)-ylidene]-3-[1-amino-1-(2-amino-phenylsulfanyl)-meth-(E)-ylidene]-succinonitrile | 2-[Amino-(2-amino-phenylsulfanyl)-methylene]-3-[1-amino-1-(2-amino-phenylsulfanyl)-meth-(Z)-ylidene]-succinonitrile | CHEMBL100473 | CHEMBL95758 | U-0126

Type

Small organic molecule

Emp. Form.

C18H16N6S2

Mol. Mass.

380.49

SMILES

Nc1ccccc1SC(=N)C(C#N)C(C#N)C(=N)Sc1ccccc1N

Structure