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TargetDipeptidyl peptidase 4
LigandBDBM50146000
Substrate/Competitorn/a
Meas. Tech.ChEMBL_53378 (CHEMBL665782)
Ki 25±n/a nM
Citation Magnin, DRRobl, JASulsky, RBAugeri, DJHuang, YSimpkins, LMTaunk, PCBetebenner, DARobertson, JGAbboa-Offei, BEWang, ACap, MXin, LTao, LSitkoff, DFMalley, MFGougoutas, JZKhanna, AHuang, QHan, SPParker, RAHamann, LG Synthesis of novel potent dipeptidyl peptidase IV inhibitors with enhanced chemical stability: interplay between the N-terminal amino acid alkyl side chain and the cyclopropyl group of alpha-aminoacyl-l-cis-4,5-methanoprolinenitrile-based inhibitors. J Med Chem47:2587-98 (2004) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dipeptidyl peptidase 4
Name:Dipeptidyl peptidase 4
Synonyms:CD26 | CD_antigen=CD26 | DPP IV | DPP4 | DPP4_PIG | Dipeptidyl peptidase 4 | Dipeptidyl peptidase 4 membrane form | Dipeptidyl peptidase 4 soluble form | Dipeptidyl peptidase IV | Dipeptidyl peptidase IV membrane form | Dipeptidyl peptidase IV soluble form | T-cell activation antigen CD26
Type:Enzyme
Mol. Mass.:88235.21
Organism:Sus scrofa (pig)
Description:n/a
Residue:766
Sequence:
MKTPWKVLLGLLGIAALVTVITVPVVLLNKGTDDAAADSRRTYTLTDYLKSTFRVKFYTL
QWISDHEYLYKQENNILLFNAEYGNSSIFLENSTFDELGYSTNDYSVSPDRQFILFEYNY
VKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWITWSPVGHKLAYVWNNDIYVKNEPNL
SSQRITWTGKENVIYNGVTDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSF
YSDESLQYPKTVRIPYPKAGAENPTVKFFVVDTRTLSPNASVTSYQIVPPASVLIGDHYL
CGVTWVTEERISLQWIRRAQNYSIIDICDYDESTGRWISSVARQHIEISTTGWVGRFRPA
EPHFTSDGNSFYKIISNEEGYKHICHFQTDKSNCTFITKGAWEVIGIEALTSDYLYYISN
EHKGMPGGRNLYRIQLNDYTKVTCLSCELNPERCQYYSASFSNKAKYYQLRCFGPGLPLY
TLHSSSSDKELRVLEDNSALDKMLQDVQMPSKKLDVINLHGTKFWYQMILPPHFDKSKKY
PLLIEVYAGPCSQKVDTVFRLSWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGT
FEVEDQIEATRQFSKMGFVDDKRIAIWGWSYGGYVTSMVLGAGSGVFKCGIAVAPVSKWE
YYDSVYTERYMGLPTPEDNLDYYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQLS
KALVDAGVDFQTMWYTDEDHGIASNMAHQHIYTHMSHFLKQCFSLP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50146000
n/a
NameBDBM50146000
Synonyms:(1S,5S)-2-((S)-2-Amino-3-methyl-pentanoyl)-2-aza-bicyclo[3.1.0]hexane-3-carbonitrile; TFA | CHEMBL315434
TypeSmall organic molecule
Emp. Form.C12H19N3O
Mol. Mass.221.2988
SMILESCCC(C)[C@H](N)C(=O)N1[C@H]2C[C@H]2CC1C#N
Structure
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