| Reaction Details |
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 | Report a problem with these data |
| Target | Dipeptidyl peptidase 4 |
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| Ligand | BDBM50146001 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_53378 (CHEMBL665782) |
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| Ki | 107±n/a nM |
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| Citation |  Magnin, DR; Robl, JA; Sulsky, RB; Augeri, DJ; Huang, Y; Simpkins, LM; Taunk, PC; Betebenner, DA; Robertson, JG; Abboa-Offei, BE; Wang, A; Cap, M; Xin, L; Tao, L; Sitkoff, DF; Malley, MF; Gougoutas, JZ; Khanna, A; Huang, Q; Han, SP; Parker, RA; Hamann, LG Synthesis of novel potent dipeptidyl peptidase IV inhibitors with enhanced chemical stability: interplay between the N-terminal amino acid alkyl side chain and the cyclopropyl group of alpha-aminoacyl-l-cis-4,5-methanoprolinenitrile-based inhibitors. J Med Chem47:2587-98 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dipeptidyl peptidase 4 |
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| Name: | Dipeptidyl peptidase 4 |
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| Synonyms: | CD26 | CD_antigen=CD26 | DPP IV | DPP4 | DPP4_PIG | Dipeptidyl peptidase 4 | Dipeptidyl peptidase 4 membrane form | Dipeptidyl peptidase 4 soluble form | Dipeptidyl peptidase IV | Dipeptidyl peptidase IV membrane form | Dipeptidyl peptidase IV soluble form | T-cell activation antigen CD26 |
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| Type: | Enzyme |
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| Mol. Mass.: | 88235.21 |
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| Organism: | Sus scrofa (pig) |
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| Description: | n/a |
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| Residue: | 766 |
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| Sequence: | MKTPWKVLLGLLGIAALVTVITVPVVLLNKGTDDAAADSRRTYTLTDYLKSTFRVKFYTL
QWISDHEYLYKQENNILLFNAEYGNSSIFLENSTFDELGYSTNDYSVSPDRQFILFEYNY
VKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWITWSPVGHKLAYVWNNDIYVKNEPNL
SSQRITWTGKENVIYNGVTDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSF
YSDESLQYPKTVRIPYPKAGAENPTVKFFVVDTRTLSPNASVTSYQIVPPASVLIGDHYL
CGVTWVTEERISLQWIRRAQNYSIIDICDYDESTGRWISSVARQHIEISTTGWVGRFRPA
EPHFTSDGNSFYKIISNEEGYKHICHFQTDKSNCTFITKGAWEVIGIEALTSDYLYYISN
EHKGMPGGRNLYRIQLNDYTKVTCLSCELNPERCQYYSASFSNKAKYYQLRCFGPGLPLY
TLHSSSSDKELRVLEDNSALDKMLQDVQMPSKKLDVINLHGTKFWYQMILPPHFDKSKKY
PLLIEVYAGPCSQKVDTVFRLSWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGT
FEVEDQIEATRQFSKMGFVDDKRIAIWGWSYGGYVTSMVLGAGSGVFKCGIAVAPVSKWE
YYDSVYTERYMGLPTPEDNLDYYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQLS
KALVDAGVDFQTMWYTDEDHGIASNMAHQHIYTHMSHFLKQCFSLP
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| BDBM50146001 |
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| n/a |
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| Name | BDBM50146001 |
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| Synonyms: | (1S,5S)-2-((S)-1-Amino-pyrrolidine-2-carbonyl)-2-aza-bicyclo[3.1.0]hexane-3-carbonitrile; TFA | CHEMBL328365 |
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| Type | Small organic molecule |
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| Emp. Form. | C11H16N4O |
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| Mol. Mass. | 220.2709 |
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| SMILES | NN1CCC[C@H]1C(=O)N1[C@H]2C[C@H]2CC1C#N |
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| Structure | 
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