Ki Summary

Reaction Details

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Target

6-phosphogluconate dehydrogenase, decarboxylating

Ligand

BDBM50148780

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_4339 (CHEMBL619158)

1100±n/a nM

Citation

Dardonville, C; Rinaldi, E; Barrett, MP; Brun, R; Gilbert, IH; Hanau, S Selective inhibition of Trypanosoma brucei 6-phosphogluconate dehydrogenase by high-energy intermediate and transition-state analogues. J Med Chem47:3427-37 (2004) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

6-phosphogluconate dehydrogenase, decarboxylating

Name:

6-phosphogluconate dehydrogenase, decarboxylating

Synonyms:

6-phosphogluconate dehydrogenase | 6-phosphogluconate dehydrogenase (6PGD) | 6PGD_HUMAN | PGD | PGDH

Type:

Protein

Mol. Mass.:

53143.42

Organism:

Homo sapiens (Human)

Description:

P52209

Residue:

483

Sequence:

MAQADIALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVDDFLANEAKGTKVVGAQSLKE
MVSKLKKPRRIILLVKAGQAVDDFIEKLVPLLDTGDIIIDGGNSEYRDTTRRCRDLKAKG
ILFVGSGVSGGEEGARYGPSLMPGGNKEAWPHIKTIFQGIAAKVGTGEPCCDWVGDEGAG
HFVKMVHNGIEYGDMQLICEAYHLMKDVLGMAQDEMAQAFEDWNKTELDSFLIEITANIL
KFQDTDGKHLLPKIRDSAGQKGTGKWTAISALEYGVPVTLIGEAVFARCLSSLKDERIQA
SKKLKGPQKFQFDGDKKSFLEDIRKALYASKIISYAQGFMLLRQAATEFGWTLNYGGIAL
MWRGGCIIRSVFLGKIKDAFDRNPELQNLLLDDFFKSAVENCQDSWRRAVSTGVQAGIPM
PCFTTALSFYDGYRHEMLPASLIQAQRDYFGAHTYELLAKPGQFIHTNWTGHGGTVSSSS
YNA

BDBM50148780

n/a

Name

BDBM50148780

Synonyms:

((4R,5R)-5-(hydroxycarbamoyl)-2,2-dimethyl-1,3-dioxolan-4-yl)methyl dihydrogen phosphate | (5-(hydroxycarbamoyl)-2,2-dimethyl-1,3-dioxolan-4-yl)methyl dihydrogen phosphate | CHEMBL324609 | Phosphoric acid mono-((R)-(R)-5-hydroxycarbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl) ester

Type

Small organic molecule

Emp. Form.

C7H14NO8P

Mol. Mass.

271.1617

SMILES

CC1(C)O[C@H](COP(O)(O)=O)[C@@H](O1)C(=O)NO

Structure