Reaction Details |
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Target | D(4) dopamine receptor |
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Ligand | BDBM50145075 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_60850 (CHEMBL675992) |
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EC50 | 23.2±n/a nM |
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Citation | Cowart, M; Latshaw, SP; Bhatia, P; Daanen, JF; Rohde, J; Nelson, SL; Patel, M; Kolasa, T; Nakane, M; Uchic, ME; Miller, LN; Terranova, MA; Chang, R; Donnelly-Roberts, DL; Namovic, MT; Hollingsworth, PR; Martino, BR; Lynch, JJ; Sullivan, JP; Hsieh, GC; Moreland, RB; Brioni, JD; Stewart, AO Discovery of 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole (ABT-724), a dopaminergic agent with a novel mode of action for the potential treatment of erectile dysfunction. J Med Chem47:3853-64 (2004) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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D(4) dopamine receptor |
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Name: | D(4) dopamine receptor |
Synonyms: | D(4) dopamine receptor | DOPAMINE D4 | DOPAMINE D4.4 | DRD4_RAT | Dopamine receptor | Drd4 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 41307.65 |
Organism: | RAT |
Description: | DOPAMINE D4.4 0 RAT::P30729 |
Residue: | 387 |
Sequence: | MGNSSATGDGGLLAGRGPESLGTGTGLGGAGAAALVGGVLLIGMVLAGNSLVCVSVASER
ILQTPTNYFIVSLAAADLLLAVLVLPLFVYSEVQGGVWLLSPRLCDTLMAMDVMLCTASI
FNLCAISVDRFVAVTVPLRYNQQGQCQLLLIAATWLLSAAVAAPVVCGLNDVPGRDPTVC
CLEDRDYVVYSSICSFFLPCPLMLLLYWATFRGLRRWEAARHTKLHSRAPRRPSGPGPPV
SDPTQGPLFSDCPPPSPSLRTSPTVSSRPESDLSQSPCSPGCLLPDAALAQPPAPSSRRK
RGAKITGRERKAMRVLPVVVGAFLMCWTPFFVVHITRALCPACFVSPRLVSAVTWLGYVN
SALNPIIYTIFNAEFRSVFRKTLRLRC
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BDBM50145075 |
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n/a |
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Name | BDBM50145075 |
Synonyms: | 2-((4-(pyridin-2-yl)piperazin-1-yl)methyl)-1H-benzo[d]imidazole | 2-(4-Pyridin-2-yl-piperazin-1-ylmethyl)-1H-benzoimidazole | ABT-724 | CHEMBL440687 |
Type | Small organic molecule |
Emp. Form. | C17H19N5 |
Mol. Mass. | 293.3663 |
SMILES | C(N1CCN(CC1)c1ccccn1)c1nc2ccccc2[nH]1 |
Structure |
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