Reaction Details |
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Target | D(4) dopamine receptor |
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Ligand | BDBM50150151 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_61169 (CHEMBL672451) |
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EC50 | 14.7±n/a nM |
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Citation | Cowart, M; Latshaw, SP; Bhatia, P; Daanen, JF; Rohde, J; Nelson, SL; Patel, M; Kolasa, T; Nakane, M; Uchic, ME; Miller, LN; Terranova, MA; Chang, R; Donnelly-Roberts, DL; Namovic, MT; Hollingsworth, PR; Martino, BR; Lynch, JJ; Sullivan, JP; Hsieh, GC; Moreland, RB; Brioni, JD; Stewart, AO Discovery of 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole (ABT-724), a dopaminergic agent with a novel mode of action for the potential treatment of erectile dysfunction. J Med Chem47:3853-64 (2004) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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D(4) dopamine receptor |
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Name: | D(4) dopamine receptor |
Synonyms: | D(2C) dopamine receptor | DOPAMINE D4 | DOPAMINE D4.2 | DOPAMINE D4.4 | DRD4 | DRD4_HUMAN | Dopamine D4 receptor |
Type: | Enzyme |
Mol. Mass.: | 48373.19 |
Organism: | Homo sapiens (Human) |
Description: | P21917 |
Residue: | 419 |
Sequence: | MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVA
TERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCT
ASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGR
DPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSG
PGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPG
LPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWT
PFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
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BDBM50150151 |
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n/a |
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Name | BDBM50150151 |
Synonyms: | 2-[4-(2-Fluoro-phenyl)-piperazin-1-ylmethyl]-1H-benzoimidazole | CHEMBL126510 |
Type | Small organic molecule |
Emp. Form. | C18H19FN4 |
Mol. Mass. | 310.3687 |
SMILES | Fc1ccccc1N1CCN(Cc2nc3ccccc3[nH]2)CC1 |
Structure |
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