Reaction Details |
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Target | Mu-type opioid receptor |
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Ligand | BDBM50139899 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_148530 (CHEMBL755191) |
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Ki | 946±n/a nM |
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Citation | Thomas, JB; Fix, SE; Rothman, RB; Mascarella, SW; Dersch, CM; Cantrell, BE; Zimmerman, DM; Carroll, FI Importance of phenolic address groups in opioid kappa receptor selective antagonists. J Med Chem47:1070-3 (2004) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Mu-type opioid receptor |
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Name: | Mu-type opioid receptor |
Synonyms: | MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | OPRM_RAT | Opiate non-selective | Opioid receptor B | Oprm1 | Ror-b |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 44503.11 |
Organism: | Rattus norvegicus (rat) |
Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor. |
Residue: | 398 |
Sequence: | MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQT
GSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST
LPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRT
PRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFA
FIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYV
IIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQ
QNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
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BDBM50139899 |
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n/a |
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Name | BDBM50139899 |
Synonyms: | CHEMBL11285 | N-{(S)-1-[(3R,4R)-4-(3-Hydroxy-phenyl)-3,4-dimethyl-piperidin-1-ylmethyl]-2-methyl-propyl}-3-phenyl-propionamide |
Type | Small organic molecule |
Emp. Form. | C27H38N2O2 |
Mol. Mass. | 422.6028 |
SMILES | CC(C)[C@@H](CN1CC[C@](C)([C@@H](C)C1)c1cccc(O)c1)NC(=O)CCc1ccccc1 |
Structure |
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