| Reaction Details |
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 | Report a problem with these data |
| Target | Potassium voltage-gated channel subfamily KQT member 1 |
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| Ligand | BDBM50099582 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_88893 (CHEMBL694796) |
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| IC50 | 120±n/a nM |
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| Citation |  Wermuth, CG Selective optimization of side activities: another way for drug discovery. J Med Chem47:1303-14 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Potassium voltage-gated channel subfamily KQT member 1 |
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| Name: | Potassium voltage-gated channel subfamily KQT member 1 |
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| Synonyms: | IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1 | KCNQ1 | KCNQ1_CAVPO | KQT-like 1 | KVLQT1 | Potassium voltage-gated channel subfamily KQT member 1 | Voltage-gated potassium channel subunit Kv7.1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 74450.11 |
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| Organism: | Cavia porcellus |
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| Description: | ChEMBL_88894 |
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| Residue: | 671 |
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| Sequence: | MAAASSPPRTERKRGGWGRLLGSRRGSASLAKKCPFSLELAEGGPAGGTLYAPVAPPGAL
SPGSPAPPASPAAPPAGLELGPRPPVSLDPRVSIYSARRPLLARTHIQGRVYNFLERPTG
WKCFVYHFAVFLIVLACLIFSVLSTIEQYAALATGTLFWMEIVLVVFFGTEYVVRLWSAG
CRSKYVGIWGRLRFARKPISIIDLIVVVASMVVLCVGSKGQVFATSAIRGIRFLQILRML
HVDRQGGTWRLLGSVVFIHRQELITTLYIGFLGLIFSSYFVYLAEKDAVNESGRVEFGSY
ADALWWGVVTVTTIGYGDKVPQTWVGKTIASCFSVFAISFFALPAGILGSGFALKVQQKQ
RQKHFNRQIPAAASLIQTAWRCYAAENPDSSTWKIYVRKPARSHTLLSPSPKPKKSAMVR
KKKFKPDKDNGVSPGEKMLTVPHITCDPPEERRPDHFSVDGYDSSVRKSPTLLEVSPTHF
MRTNSFAEDLDLEGETLLTPITHVSQLREHHRATIKVIRRMQYFVAKKKFQQARKPYDVR
DVIEQYSQGHLNLMVRIKELQRRLDQSIGKPSLFIPISEKSKDRGSNTIGARLNRVEDKV
TQLDQRLVVITDMLHQLLSLHQGGPHSGGGPQMVQPCSEDGSIHPELFLPSNSLPTYEQL
TVPQRGPDEAS
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| BDBM50099582 |
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| n/a |
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| Name | BDBM50099582 |
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| Synonyms: | (3R,4S)N-[3-Hydroxy-2,2-dimethyl-6-(4,4,4-trifluoro-butoxy)-chroman-4-yl]-N-methyl-methanesulfonamide | CHEMBL298475 | N-[(3R,4S)-3-Hydroxy-2,2-dimethyl-6-(4,4,4-trifluoro-butoxy)-chroman-4-yl]-N-methyl-methanesulfonamide | N-[3-Hydroxy-2,2-dimethyl-6-(4,4,4-trifluoro-butoxy)-chroman-4-yl]-N-methyl-methanesulfonamide |
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| Type | Small organic molecule |
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| Emp. Form. | C17H24F3NO5S |
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| Mol. Mass. | 411.436 |
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| SMILES | CN([C@@H]1[C@@H](O)C(C)(C)Oc2ccc(OCCCC(F)(F)F)cc12)S(C)(=O)=O |
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| Structure | 
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