| Reaction Details |
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 | Report a problem with these data |
| Target | Kappa-type opioid receptor |
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| Ligand | BDBM50143603 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_147223 (CHEMBL754911) |
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| Ki | 220±n/a nM |
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| Citation |  Zhang, A; Xiong, W; Hilbert, JE; DeVita, EK; Bidlack, JM; Neumeyer, JL 2-aminothiazole-derived opioids. Bioisosteric replacement of phenols. J Med Chem47:1886-8 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Kappa-type opioid receptor |
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| Name: | Kappa-type opioid receptor |
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| Synonyms: | K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR) |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 42648.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P41145 |
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| Residue: | 380 |
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| Sequence: | MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPV
IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYL
MNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINI
CIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVL
IIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALG
STSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRV
RNTVQDPAYLRDIDGMNKPV
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| BDBM50143603 |
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| n/a |
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| Name | BDBM50143603 |
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| Synonyms: | 11-amino-4-methyl-(1S,5R,16R,17S)-15-oxa-10-thia-4,12-diazahexacyclo[12.6.1.01,16.05,20.07,21.09,13]henicosa-7(21),8,11,13-tetraen-17-ol | CHEMBL294168 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H21N3O2S |
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| Mol. Mass. | 343.443 |
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| SMILES | CN1CC[C@@]23C4Oc5c2c(C[C@@H]1C3CC[C@@H]4O)cc1sc(N)nc51 |
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| Structure | 
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