Reaction Details |
| Report a problem with these data |
Target | Endothelin-1 receptor |
---|
Ligand | BDBM50061101 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_63370 (CHEMBL676106) |
---|
Ki | 6.5±n/a nM |
---|
Citation | Wu, C; Decker, ER; Blok, N; Bui, H; You, TJ; Wang, J; Bourgoyne, AR; Knowles, V; Berens, KL; Holland, GW; Brock, TA; Dixon, RA Discovery, modeling, and human pharmacokinetics of N-(2-acetyl-4,6-dimethylphenyl)-3-(3,4-dimethylisoxazol-5-ylsulfamoyl)thiophene-2-carboxamide (TBC3711), a second generation, ETA selective, and orally bioavailable endothelin antagonist. J Med Chem47:1969-86 (2004) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Endothelin-1 receptor |
---|
Name: | Endothelin-1 receptor |
Synonyms: | EDNRA_RAT | ENDOTHELIN A | Ednra | Endothelin receptor | Endothelin-1 receptor |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 48256.91 |
Organism: | RAT |
Description: | ENDOTHELIN A EDNRA RAT::P26684 |
Residue: | 426 |
Sequence: | MGVLCFLASFWLALVGGAIADNAERYSANLSSHVEDFTPFPGTEFNFLGTTLQPPNLALP
SNGSMHGYCPQQTKITTAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLITAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEQHRTCM
LNATTKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCHQSKSLMTSVPMNGTSIQWKNQEQNHNTERSS
HKDSMN
|
|
|
BDBM50061101 |
---|
n/a |
---|
Name | BDBM50061101 |
Synonyms: | 4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl) benzenesulfornamide | 4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl]benzenesulfonamide | BOSENTAN | CHEMBL957 | p-tert-Butyl-N-(6-(2-hydroxyethoxy)-5-(o-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl)benzenesulfonamide |
Type | Small organic molecule |
Emp. Form. | C27H29N5O6S |
Mol. Mass. | 551.614 |
SMILES | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(cc2)C(C)(C)C)nc(nc1OCCO)-c1ncccn1 |
Structure |
|