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TargetProthrombin
LigandBDBM50147825
Substrate/Competitorn/a
Meas. Tech.ChEMBL_208532 (CHEMBL813626)
Ki 0.840±n/a nM
Citation Young, MBBarrow, JCGlass, KLLundell, GFNewton, CLPellicore, JMRittle, KESelnick, HGStauffer, KJVacca, JPWilliams, PDBohn, DClayton, FCCook, JJKrueger, JAKuo, LCLewis, SDLucas, BJMcMasters, DRMiller-Stein, CPietrak, BLWallace, AAWhite, RBWong, BYan, YNantermet, PG Discovery and evaluation of potent P1 aryl heterocycle-based thrombin inhibitors. J Med Chem47:2995-3008 (2004) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Prothrombin
Name:Prothrombin
Synonyms:Activation peptide fragment 1 | Activation peptide fragment 2 | Coagulation factor II | F2 | Prothrombin precursor | THRB_HUMAN | Thrombin heavy chain | Thrombin light chain
Type:Protein
Mol. Mass.:70029.57
Organism:Homo sapiens (Human)
Description:P00734
Residue:622
Sequence:
MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLEREC
VEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHV
NITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQE
CSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASA
QAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETG
DGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYI
DGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTEN
DLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHP
VCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDST
RIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKY
GFYTHVFRLKKWIQKVIDQFGE
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50147825
n/a
NameBDBM50147825
Synonyms:2-[6-Chloro-3-(2,2-difluoro-2-pyridin-2-yl-ethylamino)-2-oxo-2H-pyrazin-1-yl]-N-(2-[1,2,3]thiadiazol-4-yl-benzyl)-acetamide | CHEMBL317915
TypeSmall organic molecule
Emp. Form.C22H18ClF2N7O2S
Mol. Mass.517.939
SMILESFC(F)(CNc1ncc(Cl)n(CC(=O)NCc2ccccc2-c2csnn2)c1=O)c1ccccn1
Structure
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