| Reaction Details |
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 | Report a problem with these data |
| Target | Prothrombin |
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| Ligand | BDBM50133531 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_208532 (CHEMBL813626) |
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| Ki | 250±n/a nM |
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| Citation |  Young, MB; Barrow, JC; Glass, KL; Lundell, GF; Newton, CL; Pellicore, JM; Rittle, KE; Selnick, HG; Stauffer, KJ; Vacca, JP; Williams, PD; Bohn, D; Clayton, FC; Cook, JJ; Krueger, JA; Kuo, LC; Lewis, SD; Lucas, BJ; McMasters, DR; Miller-Stein, C; Pietrak, BL; Wallace, AA; White, RB; Wong, B; Yan, Y; Nantermet, PG Discovery and evaluation of potent P1 aryl heterocycle-based thrombin inhibitors. J Med Chem47:2995-3008 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Prothrombin |
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| Name: | Prothrombin |
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| Synonyms: | Activation peptide fragment 1 | Activation peptide fragment 2 | Coagulation factor II | F2 | Prothrombin precursor | THRB_HUMAN | Thrombin heavy chain | Thrombin light chain |
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| Type: | Protein |
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| Mol. Mass.: | 70029.57 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00734 |
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| Residue: | 622 |
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| Sequence: | MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLEREC
VEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHV
NITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQE
CSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASA
QAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETG
DGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYI
DGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTEN
DLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHP
VCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDST
RIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKY
GFYTHVFRLKKWIQKVIDQFGE
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| BDBM50133531 |
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| n/a |
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| Name | BDBM50133531 |
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| Synonyms: | (S)-1-((R)-2-Amino-3-phenyl-propionyl)-pyrrolidine-2-carboxylic acid 3-chloro-benzylamide | 1-((S)-2-Amino-1-(R)-oxo-3-phenyl-propyl)-pyrrolidine-2-carboxylic acid 3-chloro-benzylamide | CHEMBL321130 | D-phenylalanyl-N-(3-chlorobenzyl)-L-prolinamide |
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| Type | Small organic molecule |
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| Emp. Form. | C21H24ClN3O2 |
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| Mol. Mass. | 385.887 |
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| SMILES | N[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCc1cccc(Cl)c1 |
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| Structure | 
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