| Reaction Details |
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 | Report a problem with these data |
| Target | C-X-C chemokine receptor type 2 |
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| Ligand | BDBM50152760 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_306403 (CHEMBL828744) |
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| IC50 | 12±n/a nM |
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| Citation |  Jin, Q; Nie, H; McCleland, BW; Widdowson, KL; Palovich, MR; Elliott, JD; Goodman, RM; Burman, M; Sarau, HM; Ward, KW; Nord, M; Orr, BM; Gorycki, PD; Busch-Petersen, J Discovery of potent and orally bioavailable N,N'-diarylurea antagonists for the CXCR2 chemokine receptor. Bioorg Med Chem Lett14:4375-8 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-X-C chemokine receptor type 2 |
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| Name: | C-X-C chemokine receptor type 2 |
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| Synonyms: | C-X-C chemokine receptor type 2 (CXCR-2) | C-X-C chemokine receptor type 2 (CXCR2) | CD_antigen=CD182 | CDw128b | CXCR-2 | CXCR2 | CXCR2_HUMAN | Chemokine receptor type 2 (CXCR2) | GRO/MGSA receptor | High affinity interleukin-8 receptor B | IL-8 receptor type 2 | IL-8R B | IL8RB | Interleukin-8 receptor B |
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| Type: | Protein |
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| Mol. Mass.: | 40767.88 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25025 |
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| Residue: | 360 |
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| Sequence: | MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFL
LSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCK
VVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPV
LLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFK
AHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATE
ILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL
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| BDBM50152760 |
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| n/a |
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| Name | BDBM50152760 |
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| Synonyms: | 3-[3-(2-Bromo-phenyl)-ureido]-6-chloro-2-hydroxy-N,N-dimethyl-benzenesulfonamide | CHEMBL183222 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H15BrClN3O4S |
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| Mol. Mass. | 448.719 |
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| SMILES | CN(C)S(=O)(=O)c1c(Cl)ccc(NC(=O)Nc2ccccc2Br)c1O |
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| Structure | 
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