| Reaction Details |
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 | Report a problem with these data |
| Target | Prostaglandin F2-alpha receptor |
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| Ligand | BDBM50150906 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_302844 (CHEMBL827889) |
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| Ki | 52±n/a nM |
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| Citation |  Selliah, RD; Hellberg, MR; Sharif, NA; McLaughlin, MA; Williams, GW; Scott, DA; Earnest, D; Haggard, KS; Dean, WD; Delgado, P; Gaines, MS; Conrow, RE; Klimko, PG AL-12182, a novel 11-oxa prostaglandin analog with topical ocular hypotensive activity in the monkey. Bioorg Med Chem Lett14:4525-8 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Prostaglandin F2-alpha receptor |
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| Name: | Prostaglandin F2-alpha receptor |
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| Synonyms: | PF2R_BOVIN | PGF receptor | PGF2 alpha receptor | PTGFR | ProstaglandinF2Alpha | Prostanoid FP receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 41044.75 |
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| Organism: | BOVINE |
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| Description: | ProstaglandinF2Alpha PTGFR BOVINE::P37289 |
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| Residue: | 362 |
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| Sequence: | MSTNSSIQPVSPESELLSNTTCQLEEDLSISFSIIFMTVGILSNSLAIAILMKAYQRFRQ
KYKSSFLLLASALVITDFFGHLINGTIAVFVYASDKDWIYFDKSNILCSIFGICMVFSGL
CPLFLGSLMAIERCIGVTKPIFHSTKITTKHVKMMLSGVCFFAVFVALLPILGHRDYKIQ
ASRTWCFYKTDEIKDWEDRFYLLLFAFLGLLALGISFVCNAITGISLLKVKFRSQQHRQG
RSHHFEMVIQLLGIMCVSCICWSPFLVTMASIGMNIQDFKDSCERTLFTLRMATWNQILD
PWVYILLRKAVLRNLYVCTRRCCGVHVISLHVWELSSIKDSLKVAAISDLPVTEKVTQQT
ST
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| BDBM50150906 |
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| n/a |
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| Name | BDBM50150906 |
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| Synonyms: | (E)-7-{(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(E)-3-hydroxy-4-(3-trifluoromethyl-phenoxy)-but-1-enyl]-cyclopentyl}-hept-5-enoic acid isopropyl ester | CHEMBL185484 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H35F3O6 |
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| Mol. Mass. | 500.5477 |
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| SMILES | CC(C)OC(=O)CCC\C=C\C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1\C=C\C(O)COc1cccc(c1)C(F)(F)F |
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| Structure | 
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