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TargetGenome polyprotein/Non-structural protein 4A
LigandBDBM50150986
Substrate/Competitorn/a
Meas. Tech.ChEMBL_303666 (CHEMBL830427)
Ki 350±n/a nM
Citation Malancona, SColarusso, SOntoria, JMMarchetti, APoma, MStansfield, ILaufer, RDi Marco, ATaliani, MVerdirame, MGonzalez-Paz, OMatassa, VGNarjes, F SAR and pharmacokinetic studies on phenethylamide inhibitors of the hepatitis C virus NS3/NS4A serine protease. Bioorg Med Chem Lett14:4575-9 (2004) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Genome polyprotein/Non-structural protein 4A
Name:Genome polyprotein/Non-structural protein 4A
Synonyms:Hepatitis C virus serine protease, NS3/NS4A
Type:n/a
Mol. Mass.:n/a
Description:ASSAY_ID of ChEMBL is 1969955
Components:This complex has 2 components.
Component 1
Name:Non-structural protein 4A
Synonyms:Hepatitis C virus NS4A protein | Hepatitis C virus serine protease, NS3/NS4A | Non-structural protein 4A
Type:PROTEIN
Mol. Mass.:5762.65
Organism:Hepatitis C virus
Description:ChEMBL_305334
Residue:54
Sequence:
STWVLLGGVLAALAAYCLSVGCVVIVGYIELGGKPALVPDKEVCYQQYDEMEEC
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Component 2
Name:Genome polyprotein
Synonyms:Hepatitis C virus NS3 protease/helicase | Hepatitis C virus serine protease, NS3/NS4A
Type:Protein
Mol. Mass.:67067.41
Organism:Hepatitis C virus
Description:A3EZI9
Residue:631
Sequence:
APITAYAQQTRGLLGCIITSLTGRDKNQVEGEVQIVSTAAQTFLATCINGVCWTVYHGAG
TRTIASSKGPVIQMYTNVDQDLVGWPAPQGARSLTPCTCGSSDLYLVTRHADVIPVRRRG
DGRGSLLSPRPISYLKGSSGGPLLCPAGHAVGIFRAAVCTRGVAKAVDFIPVEGLETTMR
SPVFSDNSSPPAVPQSYQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVAATLGFGA
YMSKAHGIDPNIRTGVRTITTGSPITYSTYGKFLADGGCSGGAYDIIICDECHSTDATSI
LGIGTVLDQAETAGARLTVLATATPPGSVTVPHPNIEEVALSTTGEIPFYGKAIPLEAIK
GGRHLIFCHSKKKCDELAAKLVALGVNAVAYYRGLDVSVIPASGDVVVVATDALMTGFTG
DFDSVIDCNTCVTQTVDFSLDPTFTIETTTLPQDAVSRTQRRGRTGRGKPGIYRFVTPGE
RPSGMFDSSVLCECYDAGCAWYELTPAETTVRLRAYMNTPGLPVCQDHLEFWEGVFTGLT
HIDAHFLSQTKQSGENLPYLVAYQATVCARAQAPPPSWDQMWKCLIRLKPTLHGPTPLLY
RLGAVQNEITLTHPITKYIMTCMSADLEVVT
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BDBM50150986
n/a
NameBDBM50150986
Synonyms:(E)-3-{3-[2-((S)-4,4-Difluoro-2-{[(2S,4S)-1-((S)-2-isobutoxycarbonylamino-3-methyl-butyryl)-4-phenyl-pyrrolidine-2-carbonyl]-amino}-butyrylamino)-ethyl]-4-fluoro-phenyl}-acrylic acid | CHEMBL435498
TypeSmall organic molecule
Emp. Form.C36H45F3N4O7
Mol. Mass.702.7603
SMILESCC(C)COC(=O)N[C@@H](C(C)C)C(=O)N1C[C@@H](C[C@H]1C(=O)N[C@@H](CC(F)F)C(=O)NCCc1cc(C=CC(O)=O)ccc1F)c1ccccc1 |w:36.37|
Structure
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