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TargetHuman immunodeficiency virus type 1 reverse transcriptase
LigandBDBM50152190
Substrate/Competitorn/a
Meas. Tech.ChEMBL_306454
IC50 114000±n/a nM
Citation Chi GNeamati NNair V Inhibition of the strand transfer step of HIV-1 integrase by non-natural dinucleotides. Bioorg Med Chem Lett 14:4815-7 (2004) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Human immunodeficiency virus type 1 reverse transcriptase
Name:Human immunodeficiency virus type 1 reverse transcriptase
Synonyms:Reverse transcriptase/RNaseH
Type:PROTEIN
Mol. Mass.:65229.15
Organism:Human immunodeficiency virus 1
Description:ChEMBL_1473730
Residue:566
Sequence:
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLVSAGIRKVLFLDGID
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  Blast E-value cutoff:
BDBM50152190
n/a
NameBDBM50152190
Synonyms:Phosphoric acid 5-(6-amino-purin-9-yl)-2-phosphonooxymethyl-tetrahydro-furan-3-yl ester 4-(6-amino-purin-9-yl)-tetrahydro-furan-2-ylmethyl ester | [5-(6-amino-9H-purin-9-yl)-2-[(phosphonatooxy)methyl]oxolan-3-yl] [4-(6-amino-9H-purin-9-yl)oxolan-2-yl]methyl phosphate
TypeSmall organic molecule
Emp. Form.C20H23N10O10P2
Mol. Mass.625.4068
SMILESNc1ncnc2n(cnc12)C1COC(COP([O-])(=O)OC2CC(OC2COP([O-])([O-])=O)n2cnc3c(N)ncnc23)C1
Structure
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