Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetSphingosine 1-phosphate receptor 2
LigandBDBM50152333
Substrate/Competitorn/a
Meas. Tech.ChEMBL_306054 (CHEMBL833010)
IC50 330±n/a nM
Citation Yan, LHale, JJLynch, CLBudhu, RGentry, AMills, SGHajdu, RKeohane, CARosenbach, MJMilligan, JAShei, GJChrebet, GBergstrom, JCard, DRosen, HMandala, SM Design and synthesis of conformationally constrained 3-(N-alkylamino)propylphosphonic acids as potent agonists of sphingosine-1-phosphate (S1P) receptors. Bioorg Med Chem Lett14:4861-6 (2004) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Sphingosine 1-phosphate receptor 2
Name:Sphingosine 1-phosphate receptor 2
Synonyms:EDG5 | S1P2 | S1PR2 | S1PR2_HUMAN | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor Edg-5 | Sphingosine-1-phosphate receptor 2 | ndothelial differentiation G-protein coupled receptor 5
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:38883.16
Organism:Homo sapiens (Human)
Description:Membranes isolated from S1P2-transfected CHO cells were used in ligand binding assay.
Residue:353
Sequence:
MGSLYSEYLNPNKVQEHYNYTKETLETQETTSRQVASAFIVILCCAIVVENLLVLIAVAR
NSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGSVTLRLTPVQWFAREGSAFITLSASV
FSLLAIAIERHVAIAKVKLYGSDKSCRMLLLIGASWLISLVLGGLPILGWNCLGHLEACS
TVLPLYAKHYVLCVVTIFSIILLAIVALYVRIYCVVRSSHADMAAPQTLALLKTVTIVLG
VFIVCWLPAFSILLLDYACPVHSCPILYKAHYFFAVSTLNSLLNPVIYTWRSRDLRREVL
RPLQCWRPGVGVQGRRRGGTPGHHLLPLRSSSSLERGMHMPTSPTFLEGNTVV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50152333
n/a
NameBDBM50152333
Synonyms:CHEMBL187588 | [2-((2R,5S)-5-Tetradecyl-pyrrolidin-2-yl)-ethyl]-phosphonic acid
TypeSmall organic molecule
Emp. Form.C20H42NO3P
Mol. Mass.375.5261
SMILESCCCCCCCCCCCCCC[C@H]1CC[C@H](CCP(O)(O)=O)N1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: