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TargetNociceptin receptor
LigandBDBM50153121
Substrate/Competitorn/a
Meas. Tech.ChEMBL_310609 (CHEMBL837187)
EC50 38.0±n/a nM
Citation Goehring, RRWhitehead, JFBrown, KIslam, KWen, XZhou, XChen, ZValenzano, KJMiller, WSShan, SKyle, DJ 1,3-Dihydro-2,1,3-benzothiadiazol-2,2-diones and 3,4-dihydro-1H-2,1,3-benzothidiazin-2,2-diones as ligands for the NOP receptor. Bioorg Med Chem Lett14:5045-50 (2004) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Nociceptin receptor
Name:Nociceptin receptor
Synonyms:KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:40702.87
Organism:Homo sapiens (Human)
Description:P41146
Residue:370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLA
VCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGN
ALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASV
VGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIR
RLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAI
LRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALAC
KTSETVPRPA
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  Blast E-value cutoff:
BDBM50153121
n/a
NameBDBM50153121
Synonyms:1-[1-(4-Isopropyl-cyclohexyl)-piperidin-4-yl]-3,4-dihydro-1H-benzo[1,2,6]thiadiazine 2,2-dioxide | CHEMBL184127 | Cis-1-[1-(4-Isopropyl-cyclohexyl)-piperidin-4-yl]-3,4-dihydro-1H-benzo[1,2,6]thiadiazine 2,2-dioxide | Trans-1-[1-(4-Isopropyl-cyclohexyl)-piperidin-4-yl]-3,4-dihydro-1H-benzo[1,2,6]thiadiazine 2,2-dioxide
TypeSmall organic molecule
Emp. Form.C21H33N3O2S
Mol. Mass.391.571
SMILESCC(C)C1CCC(CC1)N1CCC(CC1)N1c2ccccc2CNS1(=O)=O |(7.68,-3.52,;7.37,-2.01,;8.54,-.99,;5.92,-1.52,;4.78,-2.53,;3.31,-2.06,;3,-.55,;4.15,.48,;5.61,-.01,;1.55,-.05,;1.24,1.44,;-.23,1.92,;-1.37,.89,;-1.05,-.62,;.41,-1.1,;-2.82,1.37,;-3.81,.18,;-3.27,-1.27,;-4.23,-2.46,;-5.77,-2.21,;-6.31,-.77,;-5.35,.44,;-5.89,1.87,;-4.9,3.06,;-3.37,2.81,;-1.84,2.96,;-3.52,4.37,)|
Structure
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