Reaction Details |
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Target | Delta-type opioid receptor |
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Ligand | BDBM50153138 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_303251 (CHEMBL826377) |
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Ki | >2000±n/a nM |
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Citation | Goehring, RR; Whitehead, JF; Brown, K; Islam, K; Wen, X; Zhou, X; Chen, Z; Valenzano, KJ; Miller, WS; Shan, S; Kyle, DJ 1,3-Dihydro-2,1,3-benzothiadiazol-2,2-diones and 3,4-dihydro-1H-2,1,3-benzothidiazin-2,2-diones as ligands for the NOP receptor. Bioorg Med Chem Lett14:5045-50 (2004) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Delta-type opioid receptor |
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Name: | Delta-type opioid receptor |
Synonyms: | D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 40382.98 |
Organism: | Homo sapiens (Human) |
Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor. |
Residue: | 372 |
Sequence: | MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVC
AVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELL
CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVG
VPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRL
RSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAAL
HLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTAC
TPSDGPGGGAAA
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BDBM50153138 |
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n/a |
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Name | BDBM50153138 |
Synonyms: | 1-[1-(4-Benzyloxy-benzyl)-piperidin-4-yl]-1,3-dihydro-benzo[1,2,5]thiadiazole 2,2-dioxide | CHEMBL364147 |
Type | Small organic molecule |
Emp. Form. | C25H27N3O3S |
Mol. Mass. | 449.565 |
SMILES | O=S1(=O)Nc2ccccc2N1C1CCN(Cc2ccc(OCc3ccccc3)cc2)CC1 |
Structure |
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