Reaction Details | |||
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Target | Nociceptin receptor | ||
Ligand | BDBM50153134 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_310609 (CHEMBL837187) | ||
EC50 | 1609±n/a nM | ||
Citation | Goehring, RR; Whitehead, JF; Brown, K; Islam, K; Wen, X; Zhou, X; Chen, Z; Valenzano, KJ; Miller, WS; Shan, S; Kyle, DJ 1,3-Dihydro-2,1,3-benzothiadiazol-2,2-diones and 3,4-dihydro-1H-2,1,3-benzothidiazin-2,2-diones as ligands for the NOP receptor. Bioorg Med Chem Lett14:5045-50 (2004) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Nociceptin receptor | |||
Name: | Nociceptin receptor | ||
Synonyms: | KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146 | ||
Type: | G Protein-Coupled Receptor (GPCR) | ||
Mol. Mass.: | 40702.87 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P41146 | ||
Residue: | 370 | ||
Sequence: |
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BDBM50153134 | |||
n/a | |||
Name | BDBM50153134 | ||
Synonyms: | 1-[1-(4-Propyl-cyclohexyl)-piperidin-4-yl]-3,4-dihydro-1H-benzo[1,2,6]thiadiazine 2,2-dioxide | CHEMBL184260 | ||
Type | Small organic molecule | ||
Emp. Form. | C21H33N3O2S | ||
Mol. Mass. | 391.571 | ||
SMILES | CCCC1CCC(CC1)N1CCC(CC1)N1c2ccccc2CNS1(=O)=O |(9.9,-1.55,;8.44,-1.05,;7.29,-2.09,;5.82,-1.6,;4.68,-2.62,;3.22,-2.13,;2.92,-.62,;4.05,.4,;5.52,-.09,;1.46,-.14,;.31,-1.18,;-1.14,-.68,;-1.45,.82,;-.32,1.84,;1.15,1.35,;-2.91,1.28,;-3.89,.09,;-3.36,-1.34,;-4.31,-2.53,;-5.86,-2.27,;-6.39,-.85,;-5.41,.35,;-5.97,1.8,;-4.99,2.99,;-3.45,2.73,;-1.93,2.87,;-3.59,4.27,)| | ||
Structure |